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Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses

Accurate DNA replication and segregation are critical for maintaining genome integrity and suppressing cancer. Metnase and EEPD1 are DNA damage response (DDR) proteins frequently dysregulated in cancer and implicated in cancer etiology and tumor response to genotoxic chemo- and radiotherapy. Here, w...

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Detalles Bibliográficos
Autores principales:	Sharma, Neelam, Speed, Michael C, Allen, Christopher P, Maranon, David G, Williamson, Elizabeth, Singh, Sudha, Hromas, Robert, Nickoloff, Jac A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380491/ https://www.ncbi.nlm.nih.gov/pubmed/32743552 http://dx.doi.org/10.1093/narcan/zcaa008

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