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Predicting the Spread of COVID-19 Using [Formula: see text] Model Augmented to Incorporate Quarantine and Testing

India imposed a nationwide lockdown from 25th March 2020 onwards to combat the spread of COVID-19 pandemic. To model the spread of a disease and to predict its future course, epidemiologists make use of compartmental models such as the [Formula: see text] model. In order to address some of the assum...

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Autores principales: Anand, Nikhil, Sabarinath, A., Geetha, S., Somanath, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380501/
http://dx.doi.org/10.1007/s41403-020-00151-5
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author Anand, Nikhil
Sabarinath, A.
Geetha, S.
Somanath, S.
author_facet Anand, Nikhil
Sabarinath, A.
Geetha, S.
Somanath, S.
author_sort Anand, Nikhil
collection PubMed
description India imposed a nationwide lockdown from 25th March 2020 onwards to combat the spread of COVID-19 pandemic. To model the spread of a disease and to predict its future course, epidemiologists make use of compartmental models such as the [Formula: see text] model. In order to address some of the assumptions of the standard [Formula: see text] model, a new modified version of [Formula: see text] model is proposed in this paper that takes into account the percentage of infected individuals who are tested and quarantined. This approach helps overcome the assumption of homogenous mixing of population which is inherent to the conventional [Formula: see text] model. Using the available data of the number of COVID-19 positive cases reported in the state of Kerala, and in India till 26th April, 2020 and 12th May 2020, respectively, the parameter estimation problem is converted into an optimization problem with the help of a least squared cost function. The optimization problem is then solved using differential evolution optimizer. The impact of lockdown is quantified by comparing the rising trend in infections before and during the lockdown. Using the estimated set of parameters, the model predicts that in the state of Kerala, by using certain interventions the pandemic can be successfully controlled latest by the first week of July, whereas the [Formula: see text] value for India is still greater than 1, and hence lifting of lockdown from all regions of the country is not advisable.
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spelling pubmed-73805012020-07-24 Predicting the Spread of COVID-19 Using [Formula: see text] Model Augmented to Incorporate Quarantine and Testing Anand, Nikhil Sabarinath, A. Geetha, S. Somanath, S. Trans Indian Natl. Acad. Eng. Original Article India imposed a nationwide lockdown from 25th March 2020 onwards to combat the spread of COVID-19 pandemic. To model the spread of a disease and to predict its future course, epidemiologists make use of compartmental models such as the [Formula: see text] model. In order to address some of the assumptions of the standard [Formula: see text] model, a new modified version of [Formula: see text] model is proposed in this paper that takes into account the percentage of infected individuals who are tested and quarantined. This approach helps overcome the assumption of homogenous mixing of population which is inherent to the conventional [Formula: see text] model. Using the available data of the number of COVID-19 positive cases reported in the state of Kerala, and in India till 26th April, 2020 and 12th May 2020, respectively, the parameter estimation problem is converted into an optimization problem with the help of a least squared cost function. The optimization problem is then solved using differential evolution optimizer. The impact of lockdown is quantified by comparing the rising trend in infections before and during the lockdown. Using the estimated set of parameters, the model predicts that in the state of Kerala, by using certain interventions the pandemic can be successfully controlled latest by the first week of July, whereas the [Formula: see text] value for India is still greater than 1, and hence lifting of lockdown from all regions of the country is not advisable. Springer Singapore 2020-07-24 2020 /pmc/articles/PMC7380501/ http://dx.doi.org/10.1007/s41403-020-00151-5 Text en © Indian National Academy of Engineering 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Anand, Nikhil
Sabarinath, A.
Geetha, S.
Somanath, S.
Predicting the Spread of COVID-19 Using [Formula: see text] Model Augmented to Incorporate Quarantine and Testing
title Predicting the Spread of COVID-19 Using [Formula: see text] Model Augmented to Incorporate Quarantine and Testing
title_full Predicting the Spread of COVID-19 Using [Formula: see text] Model Augmented to Incorporate Quarantine and Testing
title_fullStr Predicting the Spread of COVID-19 Using [Formula: see text] Model Augmented to Incorporate Quarantine and Testing
title_full_unstemmed Predicting the Spread of COVID-19 Using [Formula: see text] Model Augmented to Incorporate Quarantine and Testing
title_short Predicting the Spread of COVID-19 Using [Formula: see text] Model Augmented to Incorporate Quarantine and Testing
title_sort predicting the spread of covid-19 using [formula: see text] model augmented to incorporate quarantine and testing
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380501/
http://dx.doi.org/10.1007/s41403-020-00151-5
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