Disease and Treatment Patterns Among Patients With Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States

BACKGROUND: Gaps exist in our understanding of the clinical course of pouch-related disorders. METHODS: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. RESULTS: Among 468 patients with an ileal pouch-anal anastomosi...

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Detalles Bibliográficos
Autores principales: Barnes, Edward L, Raffals, Laura, Long, Millie D, Syal, Gaurav, Kayal, Maia, Ananthakrishnan, Ashwin, Cohen, Benjamin, Pekow, Joel, Deepak, Parakkal, Colombel, Jean-Frederic, Herfarth, Hans H, Sandler, Robert S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Observations and Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380550/
https://www.ncbi.nlm.nih.gov/pubmed/32744536
http://dx.doi.org/10.1093/crocol/otaa039
Descripción
Sumario:BACKGROUND: Gaps exist in our understanding of the clinical course of pouch-related disorders. METHODS: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. RESULTS: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. CONCLUSIONS: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.

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