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Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression

Most clinical MRSA (methicillin-resistant S. aureus) isolates exhibit low-level β-lactam resistance (oxacillin MIC 2–4 μg/ml) due to the acquisition of a novel penicillin binding protein (PBP2A), encoded by mecA. However, strains can evolve high-level resistance (oxacillin MIC ≥256 μg/ml) by an unkn...

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Detalles Bibliográficos
Autores principales:	Panchal, Viralkumar V., Griffiths, Caitlin, Mosaei, Hamed, Bilyk, Bohdan, Sutton, Joshua A. F., Carnell, Oliver T., Hornby, David P., Green, Jeffrey, Hobbs, Jamie K., Kelley, William L., Zenkin, Nikolay, Foster, Simon J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380596/ https://www.ncbi.nlm.nih.gov/pubmed/32706832 http://dx.doi.org/10.1371/journal.ppat.1008672

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