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Promoter choice: Who should drive the CAR in T cells?

Chimeric antigen receptor (CAR) T cell therapy is an effective treatment for B cell malignancies, with emerging potential for the treatment of other hematologic cancers and solid tumors. The strength of the promoter within the CAR cassette will alter CAR-polypeptide levels on the cell surface of the...

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Detalles Bibliográficos
Autores principales:	Rad S. M., Ali Hosseini, Poudel, Aarati, Tan, Grace Min Yi, McLellan, Alexander D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380635/ https://www.ncbi.nlm.nih.gov/pubmed/32706785 http://dx.doi.org/10.1371/journal.pone.0232915

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