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Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption
We have previously demonstrated that endothelial targeting of gold nanoparticles followed by external beam irradiation can cause specific tumor vascular disruption in mouse models of cancer. The induced vascular damage may lead to changes in tumor physiology, including tumor hypoxia, thereby comprom...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380644/ https://www.ncbi.nlm.nih.gov/pubmed/32706818 http://dx.doi.org/10.1371/journal.pone.0236245 |
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author | Virani, Needa A. Kelada, Olivia J. Kunjachan, Sijumon Detappe, Alexandre Kwon, Jihun Hayashi, Jennifer Vazquez-Pagan, Ana Biancur, Douglas E. Ireland, Thomas Kumar, Rajiv Sridhar, Srinivas Makrigiorgos, G. Mike Berbeco, Ross I. |
author_facet | Virani, Needa A. Kelada, Olivia J. Kunjachan, Sijumon Detappe, Alexandre Kwon, Jihun Hayashi, Jennifer Vazquez-Pagan, Ana Biancur, Douglas E. Ireland, Thomas Kumar, Rajiv Sridhar, Srinivas Makrigiorgos, G. Mike Berbeco, Ross I. |
author_sort | Virani, Needa A. |
collection | PubMed |
description | We have previously demonstrated that endothelial targeting of gold nanoparticles followed by external beam irradiation can cause specific tumor vascular disruption in mouse models of cancer. The induced vascular damage may lead to changes in tumor physiology, including tumor hypoxia, thereby compromising future therapeutic interventions. In this study, we investigate the dynamic changes in tumor hypoxia mediated by targeted gold nanoparticles and clinical radiation therapy (RT). By using noninvasive whole-body fluorescence imaging, tumor hypoxia was measured at baseline, on day 2 and day 13, post-tumor vascular disruption. A 2.5-fold increase (P<0.05) in tumor hypoxia was measured two days after combined therapy, resolving by day 13. In addition, the combination of vascular-targeted gold nanoparticles and radiation therapy resulted in a significant (P<0.05) suppression of tumor growth. This is the first study to demonstrate the tumor hypoxic physiological response and recovery after delivery of vascular-targeted gold nanoparticles followed by clinical radiation therapy in a human non-small cell lung cancer athymic Foxn1(nu) mouse model. |
format | Online Article Text |
id | pubmed-7380644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-73806442020-07-27 Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption Virani, Needa A. Kelada, Olivia J. Kunjachan, Sijumon Detappe, Alexandre Kwon, Jihun Hayashi, Jennifer Vazquez-Pagan, Ana Biancur, Douglas E. Ireland, Thomas Kumar, Rajiv Sridhar, Srinivas Makrigiorgos, G. Mike Berbeco, Ross I. PLoS One Research Article We have previously demonstrated that endothelial targeting of gold nanoparticles followed by external beam irradiation can cause specific tumor vascular disruption in mouse models of cancer. The induced vascular damage may lead to changes in tumor physiology, including tumor hypoxia, thereby compromising future therapeutic interventions. In this study, we investigate the dynamic changes in tumor hypoxia mediated by targeted gold nanoparticles and clinical radiation therapy (RT). By using noninvasive whole-body fluorescence imaging, tumor hypoxia was measured at baseline, on day 2 and day 13, post-tumor vascular disruption. A 2.5-fold increase (P<0.05) in tumor hypoxia was measured two days after combined therapy, resolving by day 13. In addition, the combination of vascular-targeted gold nanoparticles and radiation therapy resulted in a significant (P<0.05) suppression of tumor growth. This is the first study to demonstrate the tumor hypoxic physiological response and recovery after delivery of vascular-targeted gold nanoparticles followed by clinical radiation therapy in a human non-small cell lung cancer athymic Foxn1(nu) mouse model. Public Library of Science 2020-07-24 /pmc/articles/PMC7380644/ /pubmed/32706818 http://dx.doi.org/10.1371/journal.pone.0236245 Text en © 2020 Virani et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Virani, Needa A. Kelada, Olivia J. Kunjachan, Sijumon Detappe, Alexandre Kwon, Jihun Hayashi, Jennifer Vazquez-Pagan, Ana Biancur, Douglas E. Ireland, Thomas Kumar, Rajiv Sridhar, Srinivas Makrigiorgos, G. Mike Berbeco, Ross I. Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption |
title | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption |
title_full | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption |
title_fullStr | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption |
title_full_unstemmed | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption |
title_short | Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption |
title_sort | noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380644/ https://www.ncbi.nlm.nih.gov/pubmed/32706818 http://dx.doi.org/10.1371/journal.pone.0236245 |
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