qtl2pleio: Testing pleiotropy vs. separate QTL in multiparental populations

Modern quantitative trait locus (QTL) studies in multiparental populations offer opportunities to identify causal genes for thousands of clinical and molecular traits. Traditional analyses examine each trait by itself. However, to fully leverage this vast number of measured traits, the systems genet...

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Detalles Bibliográficos
Autores principales: Boehm, Frederick, Yandell, Brian, Broman, Karl W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380654/
https://www.ncbi.nlm.nih.gov/pubmed/32715273
http://dx.doi.org/10.21105/joss.01435
Descripción
Sumario:Modern quantitative trait locus (QTL) studies in multiparental populations offer opportunities to identify causal genes for thousands of clinical and molecular traits. Traditional analyses examine each trait by itself. However, to fully leverage this vast number of measured traits, the systems genetics community needs statistical tools to analyze multiple traits simultaneously (Jiang & Zeng, 1995; Korol, Ronin, & Kirzhner, 1995). A test of pleiotropy vs. separate QTL is one such tool that will aid dissection of complex trait genetics and enhance understanding of genetic architecture.

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