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Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

Migrating cells need to coordinate distinct leading and trailing edge dynamics but the underlying mechanisms are unclear. Here, we combine experiments and mathematical modeling to elaborate the minimal autonomous biochemical machinery necessary and sufficient for this dynamic coordination and cell m...

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Detalles Bibliográficos
Autores principales: Bolado-Carrancio, Alfonso, Rukhlenko, Oleksii S, Nikonova, Elena, Tsyganov, Mikhail A, Wheeler, Anne, Garcia-Munoz, Amaya, Kolch, Walter, von Kriegsheim, Alex, Kholodenko, Boris N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380942/
https://www.ncbi.nlm.nih.gov/pubmed/32705984
http://dx.doi.org/10.7554/eLife.58165

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