Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate protein and mRNA quality control pathways. Here we found using quantitative proteomics of collided ribosomes that EDF1 is a...

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Detalles Bibliográficos
Autores principales: Juszkiewicz, Szymon, Slodkowicz, Greg, Lin, Zhewang, Freire-Pritchett, Paula, Peak-Chew, Sew-Yeu, Hegde, Ramanujan S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381030/
https://www.ncbi.nlm.nih.gov/pubmed/32657267
http://dx.doi.org/10.7554/eLife.60038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381030/
https://www.ncbi.nlm.nih.gov/pubmed/32657267
http://dx.doi.org/10.7554/eLife.60038

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