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Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress

Long non-coding RNAs (lncRNAs) are a type of non-coding RNA with a length that exceeds 200 nucleotides. Previous studies have shown that lncRNAs play an important role in the pathogenesis of various diseases. Research in both animal models and humans has begun to unravel the profound complexity of l...

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Autores principales: Zhang, Tie-Ning, Wang, Wei, Yang, Ni, Huang, Xin-Mei, Liu, Chun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381111/
https://www.ncbi.nlm.nih.gov/pubmed/32765426
http://dx.doi.org/10.3389/fendo.2020.00457
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author Zhang, Tie-Ning
Wang, Wei
Yang, Ni
Huang, Xin-Mei
Liu, Chun-Feng
author_facet Zhang, Tie-Ning
Wang, Wei
Yang, Ni
Huang, Xin-Mei
Liu, Chun-Feng
author_sort Zhang, Tie-Ning
collection PubMed
description Long non-coding RNAs (lncRNAs) are a type of non-coding RNA with a length that exceeds 200 nucleotides. Previous studies have shown that lncRNAs play an important role in the pathogenesis of various diseases. Research in both animal models and humans has begun to unravel the profound complexity of lncRNAs and demonstrated that lncRNAs exert direct effects on glucose and lipid metabolism both in vivo and in vitro. Such research has elucidated the regulatory role of lncRNAs in glucose and lipid metabolism in human disease. lncRNAs mediate glucose and lipid metabolism under physiological and pathological conditions and contribute to various metabolism disorders. This review provides an update on our understanding of the regulatory role of lncRNAs in glucose and lipid metabolism in various diseases. As our understanding of the function of lncRNAs improves, the future is promising for the development of new diagnostic biomarkers that utilize lncRNAs and treatments that target lncRNAs to improve clinical outcomes.
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spelling pubmed-73811112020-08-05 Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress Zhang, Tie-Ning Wang, Wei Yang, Ni Huang, Xin-Mei Liu, Chun-Feng Front Endocrinol (Lausanne) Endocrinology Long non-coding RNAs (lncRNAs) are a type of non-coding RNA with a length that exceeds 200 nucleotides. Previous studies have shown that lncRNAs play an important role in the pathogenesis of various diseases. Research in both animal models and humans has begun to unravel the profound complexity of lncRNAs and demonstrated that lncRNAs exert direct effects on glucose and lipid metabolism both in vivo and in vitro. Such research has elucidated the regulatory role of lncRNAs in glucose and lipid metabolism in human disease. lncRNAs mediate glucose and lipid metabolism under physiological and pathological conditions and contribute to various metabolism disorders. This review provides an update on our understanding of the regulatory role of lncRNAs in glucose and lipid metabolism in various diseases. As our understanding of the function of lncRNAs improves, the future is promising for the development of new diagnostic biomarkers that utilize lncRNAs and treatments that target lncRNAs to improve clinical outcomes. Frontiers Media S.A. 2020-07-16 /pmc/articles/PMC7381111/ /pubmed/32765426 http://dx.doi.org/10.3389/fendo.2020.00457 Text en Copyright © 2020 Zhang, Wang, Yang, Huang and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhang, Tie-Ning
Wang, Wei
Yang, Ni
Huang, Xin-Mei
Liu, Chun-Feng
Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress
title Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress
title_full Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress
title_fullStr Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress
title_full_unstemmed Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress
title_short Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress
title_sort regulation of glucose and lipid metabolism by long non-coding rnas: facts and research progress
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381111/
https://www.ncbi.nlm.nih.gov/pubmed/32765426
http://dx.doi.org/10.3389/fendo.2020.00457
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