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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques(1,2). Since previ...

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Detalles Bibliográficos
Autores principales:	Mok, Beverly Y., de Moraes, Marcos H., Zeng, Jun, Bosch, Dustin E., Kotrys, Anna V., Raguram, Aditya, Hsu, FoSheng, Radey, Matthew C., Peterson, S. Brook, Mootha, Vamsi K., Mougous, Joseph D., Liu, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381381/ https://www.ncbi.nlm.nih.gov/pubmed/32641830 http://dx.doi.org/10.1038/s41586-020-2477-4

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