Guanylate-Binding Proteins (GBPs) convert cytosolic bacteria into caspase-4 signaling platforms

Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ stimulated cells guanyl...

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Detalles Bibliográficos
Autores principales: Wandel, Michal P., Kim, Bae-Hoon, Park, Eui-Soon, Boyle, Keith B., Nayak, Komal, Lagrange, Brice, Herod, Adrian, Henry, Thomas, Zilbauer, Matthias, Rohde, John, MacMicking, John D., Randow, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381384/
https://www.ncbi.nlm.nih.gov/pubmed/32541830
http://dx.doi.org/10.1038/s41590-020-0697-2

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