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Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges
Rapid spread of coronavirus disease 2019 (COVID-19) is ravaging the globe. Since its first report in December 2019, COVID-19 cases have exploded to over 14 million as of July 2020, claiming more than 600,000 lives. Implementing fast and widespread diagnostic tests is paramount to contain COVID-19, g...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381402/ https://www.ncbi.nlm.nih.gov/pubmed/32771976 http://dx.doi.org/10.1016/j.isci.2020.101406 |
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author | Kilic, Tugba Weissleder, Ralph Lee, Hakho |
author_facet | Kilic, Tugba Weissleder, Ralph Lee, Hakho |
author_sort | Kilic, Tugba |
collection | PubMed |
description | Rapid spread of coronavirus disease 2019 (COVID-19) is ravaging the globe. Since its first report in December 2019, COVID-19 cases have exploded to over 14 million as of July 2020, claiming more than 600,000 lives. Implementing fast and widespread diagnostic tests is paramount to contain COVID-19, given the current lack of an effective therapeutic or vaccine. This review focuses on a broad description of currently available diagnostic tests to detect either the virus (SARS-CoV-2) or virus-induced immune responses. We specifically explain the working mechanisms of these tests and compare their analytical performance. These analyses will assist in selecting most effective tests for a given application, for example, epidemiology or global pandemic research, population screening, hospital-based testing, home-based and point-of-care testing, and therapeutic trials. Finally, we lay out the shortcomings of certain tests and future needs. |
format | Online Article Text |
id | pubmed-7381402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73814022020-07-28 Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges Kilic, Tugba Weissleder, Ralph Lee, Hakho iScience Review Rapid spread of coronavirus disease 2019 (COVID-19) is ravaging the globe. Since its first report in December 2019, COVID-19 cases have exploded to over 14 million as of July 2020, claiming more than 600,000 lives. Implementing fast and widespread diagnostic tests is paramount to contain COVID-19, given the current lack of an effective therapeutic or vaccine. This review focuses on a broad description of currently available diagnostic tests to detect either the virus (SARS-CoV-2) or virus-induced immune responses. We specifically explain the working mechanisms of these tests and compare their analytical performance. These analyses will assist in selecting most effective tests for a given application, for example, epidemiology or global pandemic research, population screening, hospital-based testing, home-based and point-of-care testing, and therapeutic trials. Finally, we lay out the shortcomings of certain tests and future needs. Elsevier 2020-07-25 /pmc/articles/PMC7381402/ /pubmed/32771976 http://dx.doi.org/10.1016/j.isci.2020.101406 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Kilic, Tugba Weissleder, Ralph Lee, Hakho Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges |
title | Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges |
title_full | Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges |
title_fullStr | Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges |
title_full_unstemmed | Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges |
title_short | Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges |
title_sort | molecular and immunological diagnostic tests of covid-19: current status and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381402/ https://www.ncbi.nlm.nih.gov/pubmed/32771976 http://dx.doi.org/10.1016/j.isci.2020.101406 |
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