Nox2 activation in Covid-19

Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182)...

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Detalles Bibliográficos
Autores principales: Violi, Francesco, Oliva, Alessandra, Cangemi, Roberto, Ceccarelli, Giancarlo, Pignatelli, Pasquale, Carnevale, Roberto, Cammisotto, Vittoria, Lichtner, Miriam, Alessandri, Francesco, De Angelis, Massimiliano, Miele, Maria Claudia, D'Ettorre, Gabriella, Ruberto, Franco, Venditti, Mario, Pugliese, Francesco, Mastroianni, Claudio Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381406/
https://www.ncbi.nlm.nih.gov/pubmed/32738789
http://dx.doi.org/10.1016/j.redox.2020.101655
Descripción
Sumario:Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.

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