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The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2
A handful of singular structures and laws can be observed in nature. They are not always evident but, once discovered, it seems obvious how to take advantage of them. In chemistry, the discovery of reproducible patterns stimulates the imagination to develop new functional materials and technological...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381410/ https://www.ncbi.nlm.nih.gov/pubmed/32717282 http://dx.doi.org/10.1016/j.ijpharm.2020.119689 |
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author | Garrido, Pablo F. Calvelo, Martín Blanco-González, Alexandre Veleiro, Uxía Suárez, Fabián Conde, Daniel Cabezón, Alfonso Piñeiro, Ángel Garcia-Fandino, Rebeca |
author_facet | Garrido, Pablo F. Calvelo, Martín Blanco-González, Alexandre Veleiro, Uxía Suárez, Fabián Conde, Daniel Cabezón, Alfonso Piñeiro, Ángel Garcia-Fandino, Rebeca |
author_sort | Garrido, Pablo F. |
collection | PubMed |
description | A handful of singular structures and laws can be observed in nature. They are not always evident but, once discovered, it seems obvious how to take advantage of them. In chemistry, the discovery of reproducible patterns stimulates the imagination to develop new functional materials and technological or medical applications. Two clear examples are helical structures at different levels in biological polymers as well as ring and spherical structures of different size and composition. Rings are intuitively observed as holes able to thread elongated structures. A large number of real and fictional stories have rings as inanimate protagonists. The design, development or just discovering of a special ring has often been taken as a symbol of power or success. Several examples are the Piscatory Ring wore by the Pope of the Catholic Church, the NBA Championship ring and the One Ring created by the Dark Lord Sauron in the epic story The Lord of the Rings. In this work, we reveal the power of another extremely powerful kind of rings to fight against the pandemic which is currently affecting the whole world. These rings are as small as ~1 nm of diameter and so versatile that they are able to participate in the attack of viruses, and specifically SARS-CoV-2, in a large range of different ways. This includes the encapsulation and transport of specific drugs, as adjuvants to stabilize proteins, vaccines or other molecules involved in the infection, as cholesterol trappers to destabilize the virus envelope, as carriers for RNA therapies, as direct antiviral drugs and even to rescue blood coagulation upon heparin treatment. “One ring to rule them all. One ring to find them. One ring to bring them all and in the darkness bind them.” J. R. R. Tolkien. |
format | Online Article Text |
id | pubmed-7381410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73814102020-07-28 The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2 Garrido, Pablo F. Calvelo, Martín Blanco-González, Alexandre Veleiro, Uxía Suárez, Fabián Conde, Daniel Cabezón, Alfonso Piñeiro, Ángel Garcia-Fandino, Rebeca Int J Pharm Article A handful of singular structures and laws can be observed in nature. They are not always evident but, once discovered, it seems obvious how to take advantage of them. In chemistry, the discovery of reproducible patterns stimulates the imagination to develop new functional materials and technological or medical applications. Two clear examples are helical structures at different levels in biological polymers as well as ring and spherical structures of different size and composition. Rings are intuitively observed as holes able to thread elongated structures. A large number of real and fictional stories have rings as inanimate protagonists. The design, development or just discovering of a special ring has often been taken as a symbol of power or success. Several examples are the Piscatory Ring wore by the Pope of the Catholic Church, the NBA Championship ring and the One Ring created by the Dark Lord Sauron in the epic story The Lord of the Rings. In this work, we reveal the power of another extremely powerful kind of rings to fight against the pandemic which is currently affecting the whole world. These rings are as small as ~1 nm of diameter and so versatile that they are able to participate in the attack of viruses, and specifically SARS-CoV-2, in a large range of different ways. This includes the encapsulation and transport of specific drugs, as adjuvants to stabilize proteins, vaccines or other molecules involved in the infection, as cholesterol trappers to destabilize the virus envelope, as carriers for RNA therapies, as direct antiviral drugs and even to rescue blood coagulation upon heparin treatment. “One ring to rule them all. One ring to find them. One ring to bring them all and in the darkness bind them.” J. R. R. Tolkien. Elsevier B.V. 2020-10-15 2020-07-25 /pmc/articles/PMC7381410/ /pubmed/32717282 http://dx.doi.org/10.1016/j.ijpharm.2020.119689 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Garrido, Pablo F. Calvelo, Martín Blanco-González, Alexandre Veleiro, Uxía Suárez, Fabián Conde, Daniel Cabezón, Alfonso Piñeiro, Ángel Garcia-Fandino, Rebeca The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2 |
title | The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2 |
title_full | The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2 |
title_fullStr | The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2 |
title_full_unstemmed | The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2 |
title_short | The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2 |
title_sort | lord of the nanorings: cyclodextrins and the battle against sars-cov-2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381410/ https://www.ncbi.nlm.nih.gov/pubmed/32717282 http://dx.doi.org/10.1016/j.ijpharm.2020.119689 |
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