Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading to MITA-mediated innate immune response. In t...

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Detalles Bibliográficos
Autores principales: Li, Mi, Shu, Hong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381519/
https://www.ncbi.nlm.nih.gov/pubmed/32474700
http://dx.doi.org/10.1007/s13238-020-00729-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381519/
https://www.ncbi.nlm.nih.gov/pubmed/32474700
http://dx.doi.org/10.1007/s13238-020-00729-3

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