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Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins

Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here, we present the crystal structure of recombinant Pf...

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Detalles Bibliográficos
Autores principales:	Singh, Kavita, Burkhardt, Martin, Nakuchima, Sofia, Herrera, Raul, Muratova, Olga, Gittis, Apostolos G., Kelnhofer, Emily, Reiter, Karine, Smelkinson, Margery, Veltri, Daniel, Swihart, Bruce J., Shimp, Richard, Nguyen, Vu, Zhang, Baoshan, MacDonald, Nicholas J., Duffy, Patrick E., Garboczi, David N., Narum, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381611/ https://www.ncbi.nlm.nih.gov/pubmed/32709983 http://dx.doi.org/10.1038/s42003-020-01123-9

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