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RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway
Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the role of OSBPL3 in the proliferation, invasion and metastasis of CRC remains unclear. In this...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381633/ https://www.ncbi.nlm.nih.gov/pubmed/32709922 http://dx.doi.org/10.1038/s41419-020-02793-3 |
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author | Jiao, Hong-li Weng, Bin-shu Yan, Shan-shan Lin, Zi-mo Wang, Shu-yang Chen, Xiao-ping Liang, Guang-hua Li, Xiao-Qing Zhao, Wei-yi Huang, Jia-Yi Zhang, Dan Zhang, Ling-jie Han, Fang-yi Li, Sheng-nan Chen, Li-jie Zhu, Jiong-hua He, Wen-feng Ding, Yan-qing Ye, Ya-ping |
author_facet | Jiao, Hong-li Weng, Bin-shu Yan, Shan-shan Lin, Zi-mo Wang, Shu-yang Chen, Xiao-ping Liang, Guang-hua Li, Xiao-Qing Zhao, Wei-yi Huang, Jia-Yi Zhang, Dan Zhang, Ling-jie Han, Fang-yi Li, Sheng-nan Chen, Li-jie Zhu, Jiong-hua He, Wen-feng Ding, Yan-qing Ye, Ya-ping |
author_sort | Jiao, Hong-li |
collection | PubMed |
description | Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the role of OSBPL3 in the proliferation, invasion and metastasis of CRC remains unclear. In this study, we investigated the role of OSBPL3 in CRC and found that its expression was significantly higher in CRC tissues than that in normal tissues. In addition, high expression of OSBPL3 was closely related to poor differentiation, advanced TNM stage and poor prognosis of CRC. Further experiments showed that over-expression of OSBPL3 promoted the proliferation, invasion and metastasis of CRC in vitro and in vivo models. Moreover, we revealed that OSBPL3 promoted CRC progression through activation of RAS signaling pathway. Furthermore, we demonstrated that hypoxia induced factor 1 (HIF-1A) can regulate the expression of OSBPL3 via binding to the hypoxia response element (HRE) in the promoter of OSBPL3. In summary, Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway. This novel mechanism provides a comprehensive understanding of both OSBPL3 and the RAS signaling pathway in the progression of CRC and indicates that the HIF1A–OSBPL3–RAS axis is a potential target for early therapeutic intervention in CRC progression. |
format | Online Article Text |
id | pubmed-7381633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73816332020-07-28 RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway Jiao, Hong-li Weng, Bin-shu Yan, Shan-shan Lin, Zi-mo Wang, Shu-yang Chen, Xiao-ping Liang, Guang-hua Li, Xiao-Qing Zhao, Wei-yi Huang, Jia-Yi Zhang, Dan Zhang, Ling-jie Han, Fang-yi Li, Sheng-nan Chen, Li-jie Zhu, Jiong-hua He, Wen-feng Ding, Yan-qing Ye, Ya-ping Cell Death Dis Article Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the role of OSBPL3 in the proliferation, invasion and metastasis of CRC remains unclear. In this study, we investigated the role of OSBPL3 in CRC and found that its expression was significantly higher in CRC tissues than that in normal tissues. In addition, high expression of OSBPL3 was closely related to poor differentiation, advanced TNM stage and poor prognosis of CRC. Further experiments showed that over-expression of OSBPL3 promoted the proliferation, invasion and metastasis of CRC in vitro and in vivo models. Moreover, we revealed that OSBPL3 promoted CRC progression through activation of RAS signaling pathway. Furthermore, we demonstrated that hypoxia induced factor 1 (HIF-1A) can regulate the expression of OSBPL3 via binding to the hypoxia response element (HRE) in the promoter of OSBPL3. In summary, Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway. This novel mechanism provides a comprehensive understanding of both OSBPL3 and the RAS signaling pathway in the progression of CRC and indicates that the HIF1A–OSBPL3–RAS axis is a potential target for early therapeutic intervention in CRC progression. Nature Publishing Group UK 2020-07-24 /pmc/articles/PMC7381633/ /pubmed/32709922 http://dx.doi.org/10.1038/s41419-020-02793-3 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Jiao, Hong-li Weng, Bin-shu Yan, Shan-shan Lin, Zi-mo Wang, Shu-yang Chen, Xiao-ping Liang, Guang-hua Li, Xiao-Qing Zhao, Wei-yi Huang, Jia-Yi Zhang, Dan Zhang, Ling-jie Han, Fang-yi Li, Sheng-nan Chen, Li-jie Zhu, Jiong-hua He, Wen-feng Ding, Yan-qing Ye, Ya-ping RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway |
title | RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway |
title_full | RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway |
title_fullStr | RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway |
title_full_unstemmed | RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway |
title_short | RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway |
title_sort | retracted article: upregulation of osbpl3 by hif1a promotes colorectal cancer progression through activation of ras signaling pathway |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381633/ https://www.ncbi.nlm.nih.gov/pubmed/32709922 http://dx.doi.org/10.1038/s41419-020-02793-3 |
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