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Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. 2′-O-RNA methyltransferase (MTase) is one of the enzymes of this virus that is a potential target for antiviral therapy as it is crucial for RNA cap formation; an essential process for viral RNA stabi...

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Detalles Bibliográficos
Autores principales: Krafcikova, Petra, Silhan, Jan, Nencka, Radim, Boura, Evzen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381658/
https://www.ncbi.nlm.nih.gov/pubmed/32709887
http://dx.doi.org/10.1038/s41467-020-17495-9

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