Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction

Increased pulmonary vascular permeability due to endothelial cell (EC) barrier dysfunction is a major pathological feature of acute respiratory distress syndrome/acute lung injury (ARDS/ALI), which is a devastating critical illness with high incidence and excessive mortality. Activation of NADPH oxi...

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Detalles Bibliográficos
Autores principales: Jiang, Jinyao, Huang, Kai, Xu, Shiqing, Garcia, Joe G.N., Wang, Chen, Cai, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381685/
https://www.ncbi.nlm.nih.gov/pubmed/32863203
http://dx.doi.org/10.1016/j.redox.2020.101638

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