Cargando…

Targeting the Notch and TGF-β signaling pathways to prevent retinal fibrosis in vitro and in vivo

Rationale: The Notch and transforming growth factor-β (TGFβ) signaling pathways are two intracellular mechanisms that control fibrosis in general but whether they play a major role in retinal fibrosis is less clear. Here we study how these two signaling pathways regulate Müller cell-dominated retina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Jiawen, Shen, Weiyong, Lee, So-Ra, Mathai, Ashish Easow, Zhang, Rui, Xu, Gezhi, Gillies, Mark C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381727/ https://www.ncbi.nlm.nih.gov/pubmed/32724452 http://dx.doi.org/10.7150/thno.45192

Ejemplares similares

Wogonin induces retinal neuron-like differentiation of bone marrow stem cells by inhibiting Notch-1 signaling
por: Shu, Qinmeng, et al.
Publicado: (2017)

Profiling of MicroRNAs Involved in Retinal Degeneration Caused by Selective Müller Cell Ablation
por: Chung, Sook Hyun, et al.
Publicado: (2015)

Differentiation of Retinal Glial Cells From Human Embryonic Stem Cells by Promoting the Notch Signaling Pathway
por: Chung, Sook Hyun, et al.
Publicado: (2019)

Graptopetalum paraguayense Inhibits Liver Fibrosis by Blocking TGF-β Signaling In Vivo and In Vitro
por: Hsu, Wei-Hsiang, et al.
Publicado: (2019)

Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats
por: Wang, Yi, et al.
Publicado: (2017)

Selective knockdown of hexokinase 2 in rods leads to age-related photoreceptor degeneration and retinal metabolic remodeling
por: Zhang, Rui, et al.
Publicado: (2020)

Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing
por: Baek, Suji, et al.
Publicado: (2022)

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
por: Zhang, Kun, et al.
Publicado: (2017)

Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses
por: Meyers, Jordan M., et al.
Publicado: (2018)

SURGICAL RETINAL EXPLANTS AS A SOURCE OF RETINAL PROGENITOR CELLS
por: Too, Lay Khoon, et al.
Publicado: (2021)

Oxymatrine Protects TGFβ1-Induced Retinal Fibrosis in an Animal Model of Glaucoma
por: Das, Ashmita, et al.
Publicado: (2022)

Involvement of NT3 and P75(NTR) in photoreceptor degeneration following selective Müller cell ablation
por: Shen, Weiyong, et al.
Publicado: (2013)

Notch signaling is necessary for epithelial growth arrest by TGF-β
por: Niimi, Hideki, et al.
Publicado: (2007)

Notch and TGFβ: Functional partners facilitating tumor progression
por: Ohnuki, Hidetaka, et al.
Publicado: (2014)

Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro
por: Tang, Li-xia, et al.
Publicado: (2012)

Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition
por: Mancarella, Serena, et al.
Publicado: (2022)

Differential expression of microRNAs in retinal vasculopathy caused by selective Müller cell disruption
por: Chung, Sook Hyun, et al.
Publicado: (2016)

Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions
por: Shen, Weiyong, et al.
Publicado: (2017)

The Role of TGF-β Receptors in Fibrosis
por: Nakerakanti, Sashidhar, et al.
Publicado: (2012)

Requirement of HDAC6 for activation of Notch1 by TGF-β1
por: Deskin, Brian, et al.
Publicado: (2016)

BML-111 suppresses TGF-β1-induced lung fibroblast activation in vitro and decreases experimental pulmonary fibrosis in vivo
por: Ji, Yu-Dong, et al.
Publicado: (2018)

Recombinant truncated latency-associated peptide alleviates liver fibrosis in vitro and in vivo via inhibition of TGF-β/Smad pathway
por: Song, Xudong, et al.
Publicado: (2022)

Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression
por: Yu, Chao, et al.
Publicado: (2021)

Trimetazidine inhibits liver fibrosis and hepatic stellate cell proliferation and blocks transforming growth factor-β (TGFβ)/Smad signaling in vitro and in vivo
por: Ding, Wenwen, et al.
Publicado: (2022)

Systemic Administration of Erythropoietin Inhibits Retinopathy in RCS Rats
por: Shen, Weiyong, et al.
Publicado: (2014)

Ginsenoside Rg1 Ameliorates Cigarette Smoke-Induced Airway Fibrosis by Suppressing the TGF-β1/Smad Pathway In Vivo and In Vitro
por: Guan, Sibin, et al.
Publicado: (2017)

Biochanin-A ameliorates pulmonary fibrosis by suppressing the TGF-β mediated EMT, myofibroblasts differentiation and collagen deposition in in vitro and in vivo systems
por: Andugulapati, Sai Balaji, et al.
Publicado: (2020)

Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway
por: Tang, Rong, et al.
Publicado: (2020)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Targeting TGF-β Signaling in Kidney Fibrosis
por: Isaka, Yoshitaka
Publicado: (2018)

TGF-β Pathway in Salivary Gland Fibrosis
por: Zhang, Xianglan, et al.
Publicado: (2020)

Gene Expression Changes under Cyclic Mechanical Stretching in Rat Retinal Glial (Müller) Cells
por: Wang, Xin, et al.
Publicado: (2013)

TGF-β loaded exosome enhances ischemic wound healing in vitro and in vivo
por: Shi, Ao, et al.
Publicado: (2021)

Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases
por: Veenendaal, Liesbeth M., et al.
Publicado: (2008)

Oxymatrine Inhibits Transforming Growth Factor β1 (TGF-β1)-Induced Cardiac Fibroblast-to-Myofibroblast Transformation (FMT) by Mediating the Notch Signaling Pathway In Vitro
por: Zhao, Linglu, et al.
Publicado: (2018)

Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation
por: Baumann, Bailey, et al.
Publicado: (2017)

Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
por: Blokzijl, Andries, et al.
Publicado: (2003)

Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways
por: Lv, Qun, et al.
Publicado: (2020)

Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy
por: Jiang, Tingting, et al.
Publicado: (2016)

Optogenetic restoration of high sensitivity vision with bReaChES, a red-shifted channelrhodopsin
por: Too, Lay Khoon, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s018ph73clpgnnbre81s74le9n