JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling

Background: JWA gene is known to down-regulate SP1 and reduces the expression level of Integrin αvβ3. Here, we identified a functional polypeptide (JP1) based on the active fragment of the JWA protein to suppress melanoma growth and metastasis by inhibiting the Integrin αvβ3. Methods: We conducted a...

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Detalles Bibliográficos
Autores principales: Cui, Jiahua, Shu, Chuanjun, Xu, Jin, Chen, Dongyin, Li, Jin, Ding, Kun, Chen, Minjuan, Li, Aiping, He, Jingdong, Shu, Yongqian, Yang, Liuqing, Zhang, Ruiwen, Zhou, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381750/
https://www.ncbi.nlm.nih.gov/pubmed/32724456
http://dx.doi.org/10.7150/thno.45843

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