Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children

PURPOSE: In view of the high rate of obesity and physical inactivity as well as the rising incidence of Type 2 DM among children in the neighboring Gulf countries and Middle East region; the aim of this study was, therefore, to determine the prevalence of metabolic syndrome (MetS) and prediabetes in...

Descripción completa

Detalles Bibliográficos
Autores principales: Saeed, Walid, AL-Habori, Molham, Saif-Ali, Riyadh, Al-Eryani, Ekram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381798/
https://www.ncbi.nlm.nih.gov/pubmed/32765035
http://dx.doi.org/10.2147/DMSO.S260131
_version_ 1783563120783917056
author Saeed, Walid
AL-Habori, Molham
Saif-Ali, Riyadh
Al-Eryani, Ekram
author_facet Saeed, Walid
AL-Habori, Molham
Saif-Ali, Riyadh
Al-Eryani, Ekram
author_sort Saeed, Walid
collection PubMed
description PURPOSE: In view of the high rate of obesity and physical inactivity as well as the rising incidence of Type 2 DM among children in the neighboring Gulf countries and Middle East region; the aim of this study was, therefore, to determine the prevalence of metabolic syndrome (MetS) and prediabetes in Yemeni school-aged children. PATIENTS AND METHODS: In this study, 1402 school children aged 12–13 years old (grade 7) were recruited from public schools in the capital Sana’a during the period April–May 2013. Anthropometric measurements and BP were recorded and BMI was calculated. Fasting venous blood (5 mL) was collected for biochemical analysis including FBG, HbA1c, insulin and lipids profile. Insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were calculated. RESULTS: The prevalence of prediabetes (as defined by impaired fasting glucose) and MetS (as classified by the IDF 2007) were 0.86% and 0.5%, respectively. Our results also showed 5.21% and 20.26% of the children to have two or one factor(s) of the MetS criteria fulfilled, respectively, with low HDL-c (17%) being the most prevalent MetS component, followed by metabolic glucose (8%), raised TG (5.3%), DBP (1.4%), and high WC (0.5%). Moreover, the prevalence of overweight and obesity was 4.2% and 2.8%, respectively; and about 1.2% of children had abnormal high insulin levels. Children with impaired fasting glucose (IFG) had increased HOMA-IR (p = 0.016) and SBP (p = 0.042) and decreased HDL-c (p = 0.034) and HOMA-β (p < 0.001); whereas obese children had increased WC (p < 0.001) and TG (p = 0.049). CONCLUSION: The main finding of this study is that Yemeni children are at potential risk of obesity, metabolic syndrome and prediabetes despite their low prevalences. These results highlight the need for early identification and close monitoring of children at risk of later Type 2 DM as an important primary care strategy that can effectively prevent or delay the onset of such condition.
format Online
Article
Text
id pubmed-7381798
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-73817982020-08-05 Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children Saeed, Walid AL-Habori, Molham Saif-Ali, Riyadh Al-Eryani, Ekram Diabetes Metab Syndr Obes Original Research PURPOSE: In view of the high rate of obesity and physical inactivity as well as the rising incidence of Type 2 DM among children in the neighboring Gulf countries and Middle East region; the aim of this study was, therefore, to determine the prevalence of metabolic syndrome (MetS) and prediabetes in Yemeni school-aged children. PATIENTS AND METHODS: In this study, 1402 school children aged 12–13 years old (grade 7) were recruited from public schools in the capital Sana’a during the period April–May 2013. Anthropometric measurements and BP were recorded and BMI was calculated. Fasting venous blood (5 mL) was collected for biochemical analysis including FBG, HbA1c, insulin and lipids profile. Insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were calculated. RESULTS: The prevalence of prediabetes (as defined by impaired fasting glucose) and MetS (as classified by the IDF 2007) were 0.86% and 0.5%, respectively. Our results also showed 5.21% and 20.26% of the children to have two or one factor(s) of the MetS criteria fulfilled, respectively, with low HDL-c (17%) being the most prevalent MetS component, followed by metabolic glucose (8%), raised TG (5.3%), DBP (1.4%), and high WC (0.5%). Moreover, the prevalence of overweight and obesity was 4.2% and 2.8%, respectively; and about 1.2% of children had abnormal high insulin levels. Children with impaired fasting glucose (IFG) had increased HOMA-IR (p = 0.016) and SBP (p = 0.042) and decreased HDL-c (p = 0.034) and HOMA-β (p < 0.001); whereas obese children had increased WC (p < 0.001) and TG (p = 0.049). CONCLUSION: The main finding of this study is that Yemeni children are at potential risk of obesity, metabolic syndrome and prediabetes despite their low prevalences. These results highlight the need for early identification and close monitoring of children at risk of later Type 2 DM as an important primary care strategy that can effectively prevent or delay the onset of such condition. Dove 2020-07-20 /pmc/articles/PMC7381798/ /pubmed/32765035 http://dx.doi.org/10.2147/DMSO.S260131 Text en © 2020 Saeed et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Saeed, Walid
AL-Habori, Molham
Saif-Ali, Riyadh
Al-Eryani, Ekram
Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_full Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_fullStr Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_full_unstemmed Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_short Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children
title_sort metabolic syndrome and prediabetes among yemeni school-aged children
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381798/
https://www.ncbi.nlm.nih.gov/pubmed/32765035
http://dx.doi.org/10.2147/DMSO.S260131
work_keys_str_mv AT saeedwalid metabolicsyndromeandprediabetesamongyemenischoolagedchildren
AT alhaborimolham metabolicsyndromeandprediabetesamongyemenischoolagedchildren
AT saifaliriyadh metabolicsyndromeandprediabetesamongyemenischoolagedchildren
AT aleryaniekram metabolicsyndromeandprediabetesamongyemenischoolagedchildren