The COVID-19 Drug and Gene Set Library

In a short period, many research publications that report sets of experimentally validated drugs as potential COVID-19 therapies have emerged. To organize this accumulating knowledge, we developed the COVID-19 Drug and Gene Set Library (https://amp.pharm.mssm.edu/covid19/), a collection of drug and...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuleshov, Maxim V., Stein, Daniel J., Clarke, Daniel J.B., Kropiwnicki, Eryk, Jagodnik, Kathleen M., Bartal, Alon, Evangelista, John E., Hom, Jason, Cheng, Minxuan, Bailey, Allison, Zhou, Abigail, Ferguson, Laura B., Lachmann, Alexander, Ma'ayan, Avi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381899/
https://www.ncbi.nlm.nih.gov/pubmed/32838343
http://dx.doi.org/10.1016/j.patter.2020.100090
Descripción
Sumario:In a short period, many research publications that report sets of experimentally validated drugs as potential COVID-19 therapies have emerged. To organize this accumulating knowledge, we developed the COVID-19 Drug and Gene Set Library (https://amp.pharm.mssm.edu/covid19/), a collection of drug and gene sets related to COVID-19 research from multiple sources. The platform enables users to view, download, analyze, visualize, and contribute drug and gene sets related to COVID-19 research. To evaluate the content of the library, we compared the results from six in vitro drug screens for COVID-19 repurposing candidates. Surprisingly, we observe low overlap across screens while highlighting overlapping candidates that should receive more attention as potential therapeutics for COVID-19. Overall, the COVID-19 Drug and Gene Set Library can be used to identify community consensus, make researchers and clinicians aware of new potential therapies, enable machine-learning applications, and facilitate the research community to work together toward a cure.

Ejemplares similares