The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil

Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter's syndrome. While Richter's syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less inten...

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Autores principales: Ng, Teng Fong, Carnley, Benedict, Green, Celia, Spagnolo, Dominic, Leahy, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381955/
https://www.ncbi.nlm.nih.gov/pubmed/32724682
http://dx.doi.org/10.1155/2020/8363427
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author Ng, Teng Fong
Carnley, Benedict
Green, Celia
Spagnolo, Dominic
Leahy, Michael F.
author_facet Ng, Teng Fong
Carnley, Benedict
Green, Celia
Spagnolo, Dominic
Leahy, Michael F.
author_sort Ng, Teng Fong
collection PubMed
description Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter's syndrome. While Richter's syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treatment regimens. We present a case of Richter's syndrome following treatment with chlorambucil and obinutuzumab and review of available literature on the topic.
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spelling pubmed-73819552020-07-27 The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil Ng, Teng Fong Carnley, Benedict Green, Celia Spagnolo, Dominic Leahy, Michael F. Case Rep Hematol Case Report Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter's syndrome. While Richter's syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treatment regimens. We present a case of Richter's syndrome following treatment with chlorambucil and obinutuzumab and review of available literature on the topic. Hindawi 2020-07-16 /pmc/articles/PMC7381955/ /pubmed/32724682 http://dx.doi.org/10.1155/2020/8363427 Text en Copyright © 2020 Teng Fong Ng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ng, Teng Fong
Carnley, Benedict
Green, Celia
Spagnolo, Dominic
Leahy, Michael F.
The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil
title The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil
title_full The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil
title_fullStr The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil
title_full_unstemmed The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil
title_short The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil
title_sort occurrence of richter's syndrome during treatment with obinutuzumab and chlorambucil
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381955/
https://www.ncbi.nlm.nih.gov/pubmed/32724682
http://dx.doi.org/10.1155/2020/8363427
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