Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

Tuberous sclerosis complex (TSC) is a neurogenetic disorder that leads to elevated mechanistic targeting of rapamycin complex 1 (mTORC1) activity. Cilia can be affected by mTORC1 signaling, and ciliary deficits are associated with neurodevelopmental disorders. Here, we examine whether neuronal cilia...

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Detalles Bibliográficos
Autores principales: Di Nardo, Alessia, Lenoël, Isadora, Winden, Kellen D., Rühmkorf, Alina, Modi, Meera E., Barrett, Lee, Ercan-Herbst, Ebru, Venugopal, Pooja, Behne, Robert, Lopes, Carla A.M., Kleiman, Robin J., Bettencourt-Dias, Mónica, Sahin, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381997/
https://www.ncbi.nlm.nih.gov/pubmed/32579942
http://dx.doi.org/10.1016/j.celrep.2020.107780

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