Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization

BACKGROUND: High rates of dihydroartemisinin–piperaquine (DHA–PPQ) treatment failures have been documented for uncomplicated Plasmodium falciparum in Cambodia. The genetic markers plasmepsin 2 (pfpm2), exonuclease (pfexo) and chloroquine resistance transporter (pfcrt) genes are associated with PPQ r...

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Detalles Bibliográficos
Autores principales: Boonyalai, Nonlawat, Vesely, Brian A., Thamnurak, Chatchadaporn, Praditpol, Chantida, Fagnark, Watcharintorn, Kirativanich, Kirakarn, Saingam, Piyaporn, Chaisatit, Chaiyaporn, Lertsethtakarn, Paphavee, Gosi, Panita, Kuntawunginn, Worachet, Vanachayangkul, Pattaraporn, Spring, Michele D., Fukuda, Mark M., Lon, Chanthap, Smith, Philip L., Waters, Norman C., Saunders, David L., Wojnarski, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382038/
https://www.ncbi.nlm.nih.gov/pubmed/32711538
http://dx.doi.org/10.1186/s12936-020-03339-w

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