A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

BACKGROUND: Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. The mechanisms underlying the contribution of CAA to neurodegeneration are not currently understood. Although CAA is highly associated with the accumulation of amyloid beta (Aβ), other amyloids ar...

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Detalles Bibliográficos
Autores principales: Taylor, Xavier, Cisternas, Pablo, You, Yanwen, You, Yingjian, Xiang, Shunian, Marambio, Yamil, Zhang, Jie, Vidal, Ruben, Lasagna-Reeves, Cristian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382050/
https://www.ncbi.nlm.nih.gov/pubmed/32711525
http://dx.doi.org/10.1186/s12974-020-01900-7

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