Cargando…
Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
Amla (Emblica officinalis Gaertn.) is a natural source of antioxidants and possesses valuable medicinal properties. However, the protective effect of amla in the kidney of two‐kidneys‐one‐clip (2K1C) rats has not been explained sufficiently. This study was performed to evaluate the renoprotective ef...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382108/ https://www.ncbi.nlm.nih.gov/pubmed/32724620 http://dx.doi.org/10.1002/fsn3.1640 |
_version_ | 1783563185186406400 |
---|---|
author | Rahman, Md. Mizanur Ferdous, Khandoker Usran Roy, Shraboni Nitul, Iffat Ara Mamun, Fariha Hossain, Md. Hemayet Subhan, Nusrat Alam, Md Ashraful Haque, Md. Areeful |
author_facet | Rahman, Md. Mizanur Ferdous, Khandoker Usran Roy, Shraboni Nitul, Iffat Ara Mamun, Fariha Hossain, Md. Hemayet Subhan, Nusrat Alam, Md Ashraful Haque, Md. Areeful |
author_sort | Rahman, Md. Mizanur |
collection | PubMed |
description | Amla (Emblica officinalis Gaertn.) is a natural source of antioxidants and possesses valuable medicinal properties. However, the protective effect of amla in the kidney of two‐kidneys‐one‐clip (2K1C) rats has not been explained sufficiently. This study was performed to evaluate the renoprotective effect of amla fruit powder (2.5% W/W) supplementation in kidneys of 2K1C rats. 2K1C rats increased the remnant kidney wet weight and also increased plasma creatinine and uric acid concentration compared to the control. Amla supplementation ameliorates elevated creatinine and uric acid concentration in plasma of 2K1C rats. Various oxidative stress indicators such as malondialdehyde, nitric oxide (NO), and advanced protein oxidation product (APOP) were also increased in plasma, heart, and kidney tissues in 2K1C rats that were also significantly brought down to normal level by amla supplementation. Moreover, the inflammatory cells entry and fibrosis in the 2K1C rat's tissues were prevented by amla supplementation. These research results suggest that amla may restore plasma antioxidant capacities and prevents oxidative stress, inflammation, and fibrosis in 2K1C rats. Taken these results as a base, clinical supplementation of dried amla powder in diet or juice to the CKD patients would be beneficial. |
format | Online Article Text |
id | pubmed-7382108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73821082020-07-27 Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats Rahman, Md. Mizanur Ferdous, Khandoker Usran Roy, Shraboni Nitul, Iffat Ara Mamun, Fariha Hossain, Md. Hemayet Subhan, Nusrat Alam, Md Ashraful Haque, Md. Areeful Food Sci Nutr Original Research Amla (Emblica officinalis Gaertn.) is a natural source of antioxidants and possesses valuable medicinal properties. However, the protective effect of amla in the kidney of two‐kidneys‐one‐clip (2K1C) rats has not been explained sufficiently. This study was performed to evaluate the renoprotective effect of amla fruit powder (2.5% W/W) supplementation in kidneys of 2K1C rats. 2K1C rats increased the remnant kidney wet weight and also increased plasma creatinine and uric acid concentration compared to the control. Amla supplementation ameliorates elevated creatinine and uric acid concentration in plasma of 2K1C rats. Various oxidative stress indicators such as malondialdehyde, nitric oxide (NO), and advanced protein oxidation product (APOP) were also increased in plasma, heart, and kidney tissues in 2K1C rats that were also significantly brought down to normal level by amla supplementation. Moreover, the inflammatory cells entry and fibrosis in the 2K1C rat's tissues were prevented by amla supplementation. These research results suggest that amla may restore plasma antioxidant capacities and prevents oxidative stress, inflammation, and fibrosis in 2K1C rats. Taken these results as a base, clinical supplementation of dried amla powder in diet or juice to the CKD patients would be beneficial. John Wiley and Sons Inc. 2020-05-20 /pmc/articles/PMC7382108/ /pubmed/32724620 http://dx.doi.org/10.1002/fsn3.1640 Text en © 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Rahman, Md. Mizanur Ferdous, Khandoker Usran Roy, Shraboni Nitul, Iffat Ara Mamun, Fariha Hossain, Md. Hemayet Subhan, Nusrat Alam, Md Ashraful Haque, Md. Areeful Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats |
title | Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats |
title_full | Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats |
title_fullStr | Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats |
title_full_unstemmed | Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats |
title_short | Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats |
title_sort | polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2k1c rats |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382108/ https://www.ncbi.nlm.nih.gov/pubmed/32724620 http://dx.doi.org/10.1002/fsn3.1640 |
work_keys_str_mv | AT rahmanmdmizanur polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats AT ferdouskhandokerusran polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats AT royshraboni polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats AT nituliffatara polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats AT mamunfariha polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats AT hossainmdhemayet polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats AT subhannusrat polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats AT alammdashraful polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats AT haquemdareeful polyphenoliccompoundsofamlapreventoxidativestressandfibrosisinthekidneyandheartof2k1crats |