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Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats

Amla (Emblica officinalis Gaertn.) is a natural source of antioxidants and possesses valuable medicinal properties. However, the protective effect of amla in the kidney of two‐kidneys‐one‐clip (2K1C) rats has not been explained sufficiently. This study was performed to evaluate the renoprotective ef...

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Autores principales: Rahman, Md. Mizanur, Ferdous, Khandoker Usran, Roy, Shraboni, Nitul, Iffat Ara, Mamun, Fariha, Hossain, Md. Hemayet, Subhan, Nusrat, Alam, Md Ashraful, Haque, Md. Areeful
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382108/
https://www.ncbi.nlm.nih.gov/pubmed/32724620
http://dx.doi.org/10.1002/fsn3.1640
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author Rahman, Md. Mizanur
Ferdous, Khandoker Usran
Roy, Shraboni
Nitul, Iffat Ara
Mamun, Fariha
Hossain, Md. Hemayet
Subhan, Nusrat
Alam, Md Ashraful
Haque, Md. Areeful
author_facet Rahman, Md. Mizanur
Ferdous, Khandoker Usran
Roy, Shraboni
Nitul, Iffat Ara
Mamun, Fariha
Hossain, Md. Hemayet
Subhan, Nusrat
Alam, Md Ashraful
Haque, Md. Areeful
author_sort Rahman, Md. Mizanur
collection PubMed
description Amla (Emblica officinalis Gaertn.) is a natural source of antioxidants and possesses valuable medicinal properties. However, the protective effect of amla in the kidney of two‐kidneys‐one‐clip (2K1C) rats has not been explained sufficiently. This study was performed to evaluate the renoprotective effect of amla fruit powder (2.5% W/W) supplementation in kidneys of 2K1C rats. 2K1C rats increased the remnant kidney wet weight and also increased plasma creatinine and uric acid concentration compared to the control. Amla supplementation ameliorates elevated creatinine and uric acid concentration in plasma of 2K1C rats. Various oxidative stress indicators such as malondialdehyde, nitric oxide (NO), and advanced protein oxidation product (APOP) were also increased in plasma, heart, and kidney tissues in 2K1C rats that were also significantly brought down to normal level by amla supplementation. Moreover, the inflammatory cells entry and fibrosis in the 2K1C rat's tissues were prevented by amla supplementation. These research results suggest that amla may restore plasma antioxidant capacities and prevents oxidative stress, inflammation, and fibrosis in 2K1C rats. Taken these results as a base, clinical supplementation of dried amla powder in diet or juice to the CKD patients would be beneficial.
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spelling pubmed-73821082020-07-27 Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats Rahman, Md. Mizanur Ferdous, Khandoker Usran Roy, Shraboni Nitul, Iffat Ara Mamun, Fariha Hossain, Md. Hemayet Subhan, Nusrat Alam, Md Ashraful Haque, Md. Areeful Food Sci Nutr Original Research Amla (Emblica officinalis Gaertn.) is a natural source of antioxidants and possesses valuable medicinal properties. However, the protective effect of amla in the kidney of two‐kidneys‐one‐clip (2K1C) rats has not been explained sufficiently. This study was performed to evaluate the renoprotective effect of amla fruit powder (2.5% W/W) supplementation in kidneys of 2K1C rats. 2K1C rats increased the remnant kidney wet weight and also increased plasma creatinine and uric acid concentration compared to the control. Amla supplementation ameliorates elevated creatinine and uric acid concentration in plasma of 2K1C rats. Various oxidative stress indicators such as malondialdehyde, nitric oxide (NO), and advanced protein oxidation product (APOP) were also increased in plasma, heart, and kidney tissues in 2K1C rats that were also significantly brought down to normal level by amla supplementation. Moreover, the inflammatory cells entry and fibrosis in the 2K1C rat's tissues were prevented by amla supplementation. These research results suggest that amla may restore plasma antioxidant capacities and prevents oxidative stress, inflammation, and fibrosis in 2K1C rats. Taken these results as a base, clinical supplementation of dried amla powder in diet or juice to the CKD patients would be beneficial. John Wiley and Sons Inc. 2020-05-20 /pmc/articles/PMC7382108/ /pubmed/32724620 http://dx.doi.org/10.1002/fsn3.1640 Text en © 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Rahman, Md. Mizanur
Ferdous, Khandoker Usran
Roy, Shraboni
Nitul, Iffat Ara
Mamun, Fariha
Hossain, Md. Hemayet
Subhan, Nusrat
Alam, Md Ashraful
Haque, Md. Areeful
Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
title Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
title_full Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
title_fullStr Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
title_full_unstemmed Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
title_short Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
title_sort polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2k1c rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382108/
https://www.ncbi.nlm.nih.gov/pubmed/32724620
http://dx.doi.org/10.1002/fsn3.1640
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