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Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling

Chitosan oligosaccharide (COS) is the depolymerized product of chitosan possessing various biological activities and protective effects against inflammation and oxidative injury. The aim of the present study was to investigate the antioxidant effects of COS supplements on aging‐related liver dysfunc...

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Autores principales: Wang, Yueming, Xiong, Yanlei, Zhang, Aiping, Zhao, Nannan, Zhang, Jiashen, Zhao, Dongmei, Yu, Zhenhai, Xu, Ning, Yin, Yancun, Luan, Xiying, Xiong, Yanlian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382186/
https://www.ncbi.nlm.nih.gov/pubmed/32724648
http://dx.doi.org/10.1002/fsn3.1681
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author Wang, Yueming
Xiong, Yanlei
Zhang, Aiping
Zhao, Nannan
Zhang, Jiashen
Zhao, Dongmei
Yu, Zhenhai
Xu, Ning
Yin, Yancun
Luan, Xiying
Xiong, Yanlian
author_facet Wang, Yueming
Xiong, Yanlei
Zhang, Aiping
Zhao, Nannan
Zhang, Jiashen
Zhao, Dongmei
Yu, Zhenhai
Xu, Ning
Yin, Yancun
Luan, Xiying
Xiong, Yanlian
author_sort Wang, Yueming
collection PubMed
description Chitosan oligosaccharide (COS) is the depolymerized product of chitosan possessing various biological activities and protective effects against inflammation and oxidative injury. The aim of the present study was to investigate the antioxidant effects of COS supplements on aging‐related liver dysfunction. We found that COS treatment significantly attenuated elevated liver function biomarkers and oxidative stress biomarkers and decreased antioxidative enzyme activities in liver tissues in D‐galactose (D‐gal)‐treated mice. Furthermore, COS treatment significantly upregulated the expression of Nrf2 and its downstream target genes HO‐1, NQO1, and CAT. Moreover, in vitro experiments showed that COS treatment played a vital role in protecting H(2)O(2)‐exposed L02 cells against oxidative stress by activating Nrf2 antioxidant signaling. These data indicate that COS could protect against D‐gal‐induced hepatic aging by activating Nrf2 antioxidant signaling, which may provide novel applications for the prevention and treatment of aging‐related hepatic dysfunction.
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spelling pubmed-73821862020-07-27 Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling Wang, Yueming Xiong, Yanlei Zhang, Aiping Zhao, Nannan Zhang, Jiashen Zhao, Dongmei Yu, Zhenhai Xu, Ning Yin, Yancun Luan, Xiying Xiong, Yanlian Food Sci Nutr Original Research Chitosan oligosaccharide (COS) is the depolymerized product of chitosan possessing various biological activities and protective effects against inflammation and oxidative injury. The aim of the present study was to investigate the antioxidant effects of COS supplements on aging‐related liver dysfunction. We found that COS treatment significantly attenuated elevated liver function biomarkers and oxidative stress biomarkers and decreased antioxidative enzyme activities in liver tissues in D‐galactose (D‐gal)‐treated mice. Furthermore, COS treatment significantly upregulated the expression of Nrf2 and its downstream target genes HO‐1, NQO1, and CAT. Moreover, in vitro experiments showed that COS treatment played a vital role in protecting H(2)O(2)‐exposed L02 cells against oxidative stress by activating Nrf2 antioxidant signaling. These data indicate that COS could protect against D‐gal‐induced hepatic aging by activating Nrf2 antioxidant signaling, which may provide novel applications for the prevention and treatment of aging‐related hepatic dysfunction. John Wiley and Sons Inc. 2020-06-05 /pmc/articles/PMC7382186/ /pubmed/32724648 http://dx.doi.org/10.1002/fsn3.1681 Text en © 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Wang, Yueming
Xiong, Yanlei
Zhang, Aiping
Zhao, Nannan
Zhang, Jiashen
Zhao, Dongmei
Yu, Zhenhai
Xu, Ning
Yin, Yancun
Luan, Xiying
Xiong, Yanlian
Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling
title Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling
title_full Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling
title_fullStr Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling
title_full_unstemmed Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling
title_short Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling
title_sort oligosaccharide attenuates aging‐related liver dysfunction by activating nrf2 antioxidant signaling
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382186/
https://www.ncbi.nlm.nih.gov/pubmed/32724648
http://dx.doi.org/10.1002/fsn3.1681
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