Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface

The vast majority of intracellular protein targets are refractory toward small-molecule therapeutic engagement, and additional therapeutic modalities are needed to overcome this deficiency. Here, the identification and characterization of a natural product, WDB002, reveals a therapeutic modality tha...

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Detalles Bibliográficos
Autores principales: Shigdel, Uddhav K., Lee, Seung-Joo, Sowa, Mathew E., Bowman, Brian R., Robison, Keith, Zhou, Minyun, Pua, Khian Hong, Stiles, Dylan T., Blodgett, Joshua A. V., Udwary, Daniel W., Rajczewski, Andrew T., Mann, Alan S., Mostafavi, Siavash, Hardy, Tara, Arya, Sukrat, Weng, Zhigang, Stewart, Michelle, Kenyon, Kyle, Morgenstern, Jay P., Pan, Ende, Gray, Daniel C., Pollock, Roy M., Fry, Andrew M., Klausner, Richard D., Townson, Sharon A., Verdine, Gregory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382241/
https://www.ncbi.nlm.nih.gov/pubmed/32606248
http://dx.doi.org/10.1073/pnas.2006560117

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