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Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome
BACKGROUND: The aim of this study was to investigate the prognostic value of radiofrequency ablation (RFA) plus transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients with tumor size ranging from 3.0 to 10.0 cm. MATERIAL/METHODS: We retrospectively analyzed data o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382301/ https://www.ncbi.nlm.nih.gov/pubmed/32667906 http://dx.doi.org/10.12659/MSM.923263 |
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author | Liu, Weiwen Xu, Huihong Ying, Xihui Zhang, Dengke Lai, Linqiang Wang, Linyou Tu, Jianfei Ji, Jiansong |
author_facet | Liu, Weiwen Xu, Huihong Ying, Xihui Zhang, Dengke Lai, Linqiang Wang, Linyou Tu, Jianfei Ji, Jiansong |
author_sort | Liu, Weiwen |
collection | PubMed |
description | BACKGROUND: The aim of this study was to investigate the prognostic value of radiofrequency ablation (RFA) plus transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients with tumor size ranging from 3.0 to 10.0 cm. MATERIAL/METHODS: We retrospectively analyzed data on 201 patients with medium-to-large HCC. According to treatment procedure, the patients were divided into the TACE group (n=124) and the TACE+RFA group (n=77). We recorded data on patient safety, subcapsular hepatic hematoma, large amount of ascites, liver abscess, gallbladder injury, and local skin infection. The overall survival (OS) and progression-free survival (PFS) in the 2 groups were analyzed and compared between groups. RESULTS: The median PFS was 4.00 months (3.00–5.00 months) in the TACE group and 9.13 months (6.64–11.62 months) in the TACE+RFA group (P<0.001). Median OS was 12.00 months (8.88–15.13 months) in the TACE group and 27.57 months (20.06–35.08 months) in the TACE+RFA group (P<0.001). In the TACE+RFA group, multivariate Cox regression analysis showed that tumor size ≤5 cm) (HR: 1.952, 95% CI: 1.213–3.143, P=0.006), hepatitis B (HR: 2.323, 95% CI: 1.096–4.923, P=0.028), TACE times (1 or >1) (HR: 1.867, 95% CI: 1.156–3.013, P=0.011), alpha-fetoprotein (AFP) level >200 ng/ml (HR: 2.426, 95% CI: 1.533–3.839, P<0.001), and AST level >40 U/L (HR: 1.946, 95% CI: 1.196–3.166, P=0.007) were independent prognostic factors for overall survival. CONCLUSIONS: Combination therapy of TACE with RFA is a safe and effective treatment for patients with medium-to-large HCC, with the long-term beneficial effect of retarding tumor progression and improving PFS and OS. |
format | Online Article Text |
id | pubmed-7382301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73823012020-08-03 Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome Liu, Weiwen Xu, Huihong Ying, Xihui Zhang, Dengke Lai, Linqiang Wang, Linyou Tu, Jianfei Ji, Jiansong Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to investigate the prognostic value of radiofrequency ablation (RFA) plus transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients with tumor size ranging from 3.0 to 10.0 cm. MATERIAL/METHODS: We retrospectively analyzed data on 201 patients with medium-to-large HCC. According to treatment procedure, the patients were divided into the TACE group (n=124) and the TACE+RFA group (n=77). We recorded data on patient safety, subcapsular hepatic hematoma, large amount of ascites, liver abscess, gallbladder injury, and local skin infection. The overall survival (OS) and progression-free survival (PFS) in the 2 groups were analyzed and compared between groups. RESULTS: The median PFS was 4.00 months (3.00–5.00 months) in the TACE group and 9.13 months (6.64–11.62 months) in the TACE+RFA group (P<0.001). Median OS was 12.00 months (8.88–15.13 months) in the TACE group and 27.57 months (20.06–35.08 months) in the TACE+RFA group (P<0.001). In the TACE+RFA group, multivariate Cox regression analysis showed that tumor size ≤5 cm) (HR: 1.952, 95% CI: 1.213–3.143, P=0.006), hepatitis B (HR: 2.323, 95% CI: 1.096–4.923, P=0.028), TACE times (1 or >1) (HR: 1.867, 95% CI: 1.156–3.013, P=0.011), alpha-fetoprotein (AFP) level >200 ng/ml (HR: 2.426, 95% CI: 1.533–3.839, P<0.001), and AST level >40 U/L (HR: 1.946, 95% CI: 1.196–3.166, P=0.007) were independent prognostic factors for overall survival. CONCLUSIONS: Combination therapy of TACE with RFA is a safe and effective treatment for patients with medium-to-large HCC, with the long-term beneficial effect of retarding tumor progression and improving PFS and OS. International Scientific Literature, Inc. 2020-07-15 /pmc/articles/PMC7382301/ /pubmed/32667906 http://dx.doi.org/10.12659/MSM.923263 Text en © Med Sci Monit, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Liu, Weiwen Xu, Huihong Ying, Xihui Zhang, Dengke Lai, Linqiang Wang, Linyou Tu, Jianfei Ji, Jiansong Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome |
title | Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome |
title_full | Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome |
title_fullStr | Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome |
title_full_unstemmed | Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome |
title_short | Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome |
title_sort | radiofrequency ablation (rfa) combined with transcatheter arterial chemoembolization (tace) for patients with medium-to-large hepatocellular carcinoma: a retrospective analysis of long-term outcome |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382301/ https://www.ncbi.nlm.nih.gov/pubmed/32667906 http://dx.doi.org/10.12659/MSM.923263 |
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