Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS

Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation of BV-2 microglial cells. The results show that pre-treatment with GLE decreased expression of pro-inflammatory cytoki...

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Detalles Bibliográficos
Autores principales: Hilliard, Aaron, Mendonca, Patricia, Soliman, Karam F.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382303/
https://www.ncbi.nlm.nih.gov/pubmed/32480240
http://dx.doi.org/10.1016/j.jneuroim.2020.577269
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author Hilliard, Aaron
Mendonca, Patricia
Soliman, Karam F.A.
author_facet Hilliard, Aaron
Mendonca, Patricia
Soliman, Karam F.A.
author_sort Hilliard, Aaron
collection PubMed
description Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation of BV-2 microglial cells. The results show that pre-treatment with GLE decreased expression of pro-inflammatory cytokines: G-CSF, IL1-α, MCP-5, MIP3α, and, with a higher effect in MIP3α. In RT-PCR assays, pre-treatment with GLE decreased mRNA expression of CHUK, NFκB1/p150, and IKBKE (NFƙB signaling), which may be associated with the neuropathology of Alzheimer’s disease. The data show GLE inhibiting ability on pro-inflammatory mediators’ release and suggest a potential role of GLE in neurodegenerative disease prevention.
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spelling pubmed-73823032021-08-15 Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS Hilliard, Aaron Mendonca, Patricia Soliman, Karam F.A. J Neuroimmunol Article Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation of BV-2 microglial cells. The results show that pre-treatment with GLE decreased expression of pro-inflammatory cytokines: G-CSF, IL1-α, MCP-5, MIP3α, and, with a higher effect in MIP3α. In RT-PCR assays, pre-treatment with GLE decreased mRNA expression of CHUK, NFκB1/p150, and IKBKE (NFƙB signaling), which may be associated with the neuropathology of Alzheimer’s disease. The data show GLE inhibiting ability on pro-inflammatory mediators’ release and suggest a potential role of GLE in neurodegenerative disease prevention. 2020-05-26 2020-08-15 /pmc/articles/PMC7382303/ /pubmed/32480240 http://dx.doi.org/10.1016/j.jneuroim.2020.577269 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Hilliard, Aaron
Mendonca, Patricia
Soliman, Karam F.A.
Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS
title Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS
title_full Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS
title_fullStr Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS
title_full_unstemmed Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS
title_short Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS
title_sort involvement of nfƙb and mapk signaling pathways in the preventive effects of ganoderma lucidum on the inflammation of bv-2 microglial cells induced by lps
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382303/
https://www.ncbi.nlm.nih.gov/pubmed/32480240
http://dx.doi.org/10.1016/j.jneuroim.2020.577269
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