Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population

Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstruc...

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Autores principales: Kirtipal, Nikhil, Thakur, Hitender, Sobti, Ranbir Chander, Janmeja, Ashok Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382402/
https://www.ncbi.nlm.nih.gov/pubmed/32802897
http://dx.doi.org/10.22099/mbrc.2019.34594.1431
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author Kirtipal, Nikhil
Thakur, Hitender
Sobti, Ranbir Chander
Janmeja, Ashok Kumar
author_facet Kirtipal, Nikhil
Thakur, Hitender
Sobti, Ranbir Chander
Janmeja, Ashok Kumar
author_sort Kirtipal, Nikhil
collection PubMed
description Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the protagonist of IL6 (-174 G/C) genotypes as an essential risk factor for COPD in north Indian population. In the study, a total of 200 clinically diagnosed patients with COPD were selected against 200 patients. Statistical analysis reveleaed that there was no significant association between the IL6 -174 G/C genetic polymorphism and the risk of COPD (P>0.05).
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spelling pubmed-73824022020-08-13 Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population Kirtipal, Nikhil Thakur, Hitender Sobti, Ranbir Chander Janmeja, Ashok Kumar Mol Biol Res Commun Short Communication Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the protagonist of IL6 (-174 G/C) genotypes as an essential risk factor for COPD in north Indian population. In the study, a total of 200 clinically diagnosed patients with COPD were selected against 200 patients. Statistical analysis reveleaed that there was no significant association between the IL6 -174 G/C genetic polymorphism and the risk of COPD (P>0.05). Shiraz University 2020-06 /pmc/articles/PMC7382402/ /pubmed/32802897 http://dx.doi.org/10.22099/mbrc.2019.34594.1431 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Kirtipal, Nikhil
Thakur, Hitender
Sobti, Ranbir Chander
Janmeja, Ashok Kumar
Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
title Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
title_full Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
title_fullStr Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
title_full_unstemmed Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
title_short Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
title_sort association between il6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north indian population
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382402/
https://www.ncbi.nlm.nih.gov/pubmed/32802897
http://dx.doi.org/10.22099/mbrc.2019.34594.1431
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