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Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy
AIM: Survival outcomes in elderly patients with pathological stages (pStages) II and III gastric cancer remain inadequately elucidated. We retrospectively analyzed outcomes of elderly and nonelderly patients who underwent curative gastrectomy for this cancer and considered clinical results of the Es...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382424/ https://www.ncbi.nlm.nih.gov/pubmed/32724887 http://dx.doi.org/10.1002/ags3.12339 |
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author | Takahashi, Ryo Nunobe, Souya Makuuchi, Rie Ida, Satoshi Kumagai, Koshi Ohashi, Manabu Sano, Takeshi |
author_facet | Takahashi, Ryo Nunobe, Souya Makuuchi, Rie Ida, Satoshi Kumagai, Koshi Ohashi, Manabu Sano, Takeshi |
author_sort | Takahashi, Ryo |
collection | PubMed |
description | AIM: Survival outcomes in elderly patients with pathological stages (pStages) II and III gastric cancer remain inadequately elucidated. We retrospectively analyzed outcomes of elderly and nonelderly patients who underwent curative gastrectomy for this cancer and considered clinical results of the Estimation of Physiologic Ability and Surgical Stress (E‐PASS) scoring system for prediction. METHODS: Among 1041 patients who underwent gastrectomy for pStages II and III gastric cancer between 2008 and 2013 consecutively, 898 patients were enrolled. Of these, 158 patients (17.6%) were elderly and 740 patients (82.4%) were nonelderly. RESULTS: Disease‐specific survival (DSS) in the elderly group with pStage III cancer was significantly worse than that in the same stage nonelderly group (P = .001), while there was no difference in DSS for pStage II cancer between the groups (P = .45). Overall survival (OS) was significantly worse in elderly patients for both pStages II and III. Elderly patients with pStage II cancer had larger survival gaps between OS and DSS compared with those with pStage III cancer. OS for elderly patients with comprehensive risk score (CRS) > 0.159 was significantly worse than that for elderly patients with CRS ≤ 0.159 in pStage II cancer. CONCLUSIONS: Compared with nonelderly patients, different characteristics were observed in the survival outcomes of elderly patients between pStages II and III gastric cancer. The survival gap between OS and DSS of elderly patients was larger in pStage II cancer than in pStage III cancer. The E‐PASS scoring system could be a relatively useful predictor in elderly patients. |
format | Online Article Text |
id | pubmed-7382424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73824242020-07-27 Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy Takahashi, Ryo Nunobe, Souya Makuuchi, Rie Ida, Satoshi Kumagai, Koshi Ohashi, Manabu Sano, Takeshi Ann Gastroenterol Surg Original Articles AIM: Survival outcomes in elderly patients with pathological stages (pStages) II and III gastric cancer remain inadequately elucidated. We retrospectively analyzed outcomes of elderly and nonelderly patients who underwent curative gastrectomy for this cancer and considered clinical results of the Estimation of Physiologic Ability and Surgical Stress (E‐PASS) scoring system for prediction. METHODS: Among 1041 patients who underwent gastrectomy for pStages II and III gastric cancer between 2008 and 2013 consecutively, 898 patients were enrolled. Of these, 158 patients (17.6%) were elderly and 740 patients (82.4%) were nonelderly. RESULTS: Disease‐specific survival (DSS) in the elderly group with pStage III cancer was significantly worse than that in the same stage nonelderly group (P = .001), while there was no difference in DSS for pStage II cancer between the groups (P = .45). Overall survival (OS) was significantly worse in elderly patients for both pStages II and III. Elderly patients with pStage II cancer had larger survival gaps between OS and DSS compared with those with pStage III cancer. OS for elderly patients with comprehensive risk score (CRS) > 0.159 was significantly worse than that for elderly patients with CRS ≤ 0.159 in pStage II cancer. CONCLUSIONS: Compared with nonelderly patients, different characteristics were observed in the survival outcomes of elderly patients between pStages II and III gastric cancer. The survival gap between OS and DSS of elderly patients was larger in pStage II cancer than in pStage III cancer. The E‐PASS scoring system could be a relatively useful predictor in elderly patients. John Wiley and Sons Inc. 2020-04-24 /pmc/articles/PMC7382424/ /pubmed/32724887 http://dx.doi.org/10.1002/ags3.12339 Text en © 2020 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Takahashi, Ryo Nunobe, Souya Makuuchi, Rie Ida, Satoshi Kumagai, Koshi Ohashi, Manabu Sano, Takeshi Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy |
title | Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy |
title_full | Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy |
title_fullStr | Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy |
title_full_unstemmed | Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy |
title_short | Survival outcomes of elderly patients with pathological stages II and III gastric cancer following curative gastrectomy |
title_sort | survival outcomes of elderly patients with pathological stages ii and iii gastric cancer following curative gastrectomy |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382424/ https://www.ncbi.nlm.nih.gov/pubmed/32724887 http://dx.doi.org/10.1002/ags3.12339 |
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