Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors

FGF-2 displays multifarious functions in regulation of angiogenesis and vascular remodeling. However, effective drugs for treating FGF-2(+) tumors are unavailable. Here we show that FGF-2 modulates tumor vessels by recruiting NG2(+) pricytes onto tumor microvessels through a PDGFRβ-dependent mechani...

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Detalles Bibliográficos
Autores principales: Hosaka, Kayoko, Yang, Yunlong, Seki, Takahiro, Du, Qiqiao, Jing, Xu, He, Xingkang, Wu, Jieyu, Zhang, Yin, Morikawa, Hiromasa, Nakamura, Masaki, Scherzer, Martin, Sun, Xiaoting, Xu, Yuanfu, Cheng, Tao, Li, Xuri, Liu, Xialin, Li, Qi, Liu, Yizhi, Hong, An, Chen, Yuguo, Cao, Yihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382445/
https://www.ncbi.nlm.nih.gov/pubmed/32709869
http://dx.doi.org/10.1038/s41467-020-17525-6

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