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Sequential immunization induces strong and broad immunity against all four dengue virus serotypes
A major challenge in dengue vaccine development is the need to induce immunity against four dengue (DENV) serotypes. Dengvaxia®, the only licensed dengue vaccine, consists of four variant dengue antigens, one for each serotype. Three doses of immunization with the tetravalent vaccine induced only su...
Autores principales: | Hou, Jue, Shrivastava, Shubham, Loo, Hooi Linn, Wong, Lan Hiong, Ooi, Eng Eong, Chen, Jianzhu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382454/ https://www.ncbi.nlm.nih.gov/pubmed/32728482 http://dx.doi.org/10.1038/s41541-020-00216-0 |
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