Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a member of MAP3K family, is associated with aging, inflammation, oxidative stress, and related diseases, such as CHF. MLK3 h...

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Detalles Bibliográficos
Autores principales: Wang, Junyan, Deng, Bo, Liu, Qing, Huang, Yusheng, Chen, Weitao, Li, Jing, Zhou, Zheng, Zhang, Lu, Liang, Birong, He, Jiaqi, Chen, Zixin, Yan, Cui, Yang, Zhongqi, Xian, Shaoxiang, Wang, Lingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382480/
https://www.ncbi.nlm.nih.gov/pubmed/32710001
http://dx.doi.org/10.1038/s41419-020-02777-3

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