Long Non-Coding RNAs in Drug Resistance of Breast Cancer

Breast cancer (BC) is the most common cancer and the leading cause of death in women. Advances in early diagnosis and therapeutic strategies have decreased the mortality of BC and improved the prognosis of patients to some extent. However, the development of drug resistance has limited the success r...

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Autores principales: Du, Tonghua, Shi, Ying, Xu, Shengnan, Wan, Xiaoyu, Sun, Haiyin, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382578/
https://www.ncbi.nlm.nih.gov/pubmed/32764993
http://dx.doi.org/10.2147/OTT.S255226
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author Du, Tonghua
Shi, Ying
Xu, Shengnan
Wan, Xiaoyu
Sun, Haiyin
Liu, Bin
author_facet Du, Tonghua
Shi, Ying
Xu, Shengnan
Wan, Xiaoyu
Sun, Haiyin
Liu, Bin
author_sort Du, Tonghua
collection PubMed
description Breast cancer (BC) is the most common cancer and the leading cause of death in women. Advances in early diagnosis and therapeutic strategies have decreased the mortality of BC and improved the prognosis of patients to some extent. However, the development of drug resistance has limited the success rate of systemic therapies. Long non-coding RNAs (lncRNAs) are involved in drug resistance in BC via various mechanisms, which contribute to a complex regulatory network. In this review, we summarize the latest findings on the mechanisms underlying drug resistance modulated by lncRNAs in BC. In addition, we discuss the potential clinical applications of lncRNAs as targeted molecular therapy against drug resistance in BC.
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spelling pubmed-73825782020-08-05 Long Non-Coding RNAs in Drug Resistance of Breast Cancer Du, Tonghua Shi, Ying Xu, Shengnan Wan, Xiaoyu Sun, Haiyin Liu, Bin Onco Targets Ther Review Breast cancer (BC) is the most common cancer and the leading cause of death in women. Advances in early diagnosis and therapeutic strategies have decreased the mortality of BC and improved the prognosis of patients to some extent. However, the development of drug resistance has limited the success rate of systemic therapies. Long non-coding RNAs (lncRNAs) are involved in drug resistance in BC via various mechanisms, which contribute to a complex regulatory network. In this review, we summarize the latest findings on the mechanisms underlying drug resistance modulated by lncRNAs in BC. In addition, we discuss the potential clinical applications of lncRNAs as targeted molecular therapy against drug resistance in BC. Dove 2020-07-21 /pmc/articles/PMC7382578/ /pubmed/32764993 http://dx.doi.org/10.2147/OTT.S255226 Text en © 2020 Du et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Du, Tonghua
Shi, Ying
Xu, Shengnan
Wan, Xiaoyu
Sun, Haiyin
Liu, Bin
Long Non-Coding RNAs in Drug Resistance of Breast Cancer
title Long Non-Coding RNAs in Drug Resistance of Breast Cancer
title_full Long Non-Coding RNAs in Drug Resistance of Breast Cancer
title_fullStr Long Non-Coding RNAs in Drug Resistance of Breast Cancer
title_full_unstemmed Long Non-Coding RNAs in Drug Resistance of Breast Cancer
title_short Long Non-Coding RNAs in Drug Resistance of Breast Cancer
title_sort long non-coding rnas in drug resistance of breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382578/
https://www.ncbi.nlm.nih.gov/pubmed/32764993
http://dx.doi.org/10.2147/OTT.S255226
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