Correlation of drug resistance with single nucleotide variations through genome analysis and experimental validation in a multi-drug resistant clinical isolate of M. tuberculosis

BACKGROUND: Genome sequencing and genetic polymorphism analysis of clinical isolates of M. tuberculosis is carried out to gain further insight into molecular pathogenesis and host-pathogen interaction. Therefore the functional evaluation of the effect of single nucleotide variation (SNV) is essentia...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Kausik, Nemaysh, Vishal, Joon, Monika, Pratap, Ramendra, Varma-Basil, Mandira, Bose, Mridula, Brahmachari, Vani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382824/
https://www.ncbi.nlm.nih.gov/pubmed/32711461
http://dx.doi.org/10.1186/s12866-020-01912-6

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