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Changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies

BACKGROUND: Immune-mediated inflammatory diseases (IMIDs) are systemic diseases of multifactorial etiology that share aberrant immune responses as the common final pathway. With rising globalization, their incidence is increasing in developing countries and among immigrants. Our primary objective wa...

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Autores principales: Agrawal, Manasi, Shah, Shailja, Patel, Anish, Pinotti, Rachel, Colombel, Jean-Frederic, Burisch, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382899/
https://www.ncbi.nlm.nih.gov/pubmed/31351784
http://dx.doi.org/10.1016/j.jaut.2019.07.002
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author Agrawal, Manasi
Shah, Shailja
Patel, Anish
Pinotti, Rachel
Colombel, Jean-Frederic
Burisch, Johan
author_facet Agrawal, Manasi
Shah, Shailja
Patel, Anish
Pinotti, Rachel
Colombel, Jean-Frederic
Burisch, Johan
author_sort Agrawal, Manasi
collection PubMed
description BACKGROUND: Immune-mediated inflammatory diseases (IMIDs) are systemic diseases of multifactorial etiology that share aberrant immune responses as the common final pathway. With rising globalization, their incidence is increasing in developing countries and among immigrants. Our primary objective was to systematically review the epidemiology of IMIDs in immigrants and conduct a meta-analysis to estimate the risk of IMIDs in immigrant populations according to their origin and destination countries. METHODS: We systematically searched five biomedical databases and reviewed population-based studies, from inception through August 2018, that reported incidence or prevalence data of inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis (AS) or psoriasis and psoriatic arthritis (PPA) among immigrants and the host population. RESULTS: The incidence and prevalence of IMIDs among immigrants differ from host populations, and evolve over subsequent generations. The risk of IBD among immigrants approximates that in hosts, especially among South Asians, with ulcerative colitis incidence changing prior to Crohn’s disease incidence. MS risk is highest in Iranian immigrants, T1D in African immigrants and SLE in African and Iraqi immigrants. Data on other IMIDs are sparse. Significant heterogeneity between the studies precluded meta-analysis. CONCLUSION: Based on our systematic review, the epidemiology of IMIDs among immigrants varies according to native and host countries, immigrant generation, and IMID type. The rapid evolution suggests a role for non-genetic factors and gene-environment interactions. Future studies should focus on these pattern shifts, given implications of rising global burden of IMIDs and immigration.
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spelling pubmed-73828992020-12-01 Changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies Agrawal, Manasi Shah, Shailja Patel, Anish Pinotti, Rachel Colombel, Jean-Frederic Burisch, Johan J Autoimmun Article BACKGROUND: Immune-mediated inflammatory diseases (IMIDs) are systemic diseases of multifactorial etiology that share aberrant immune responses as the common final pathway. With rising globalization, their incidence is increasing in developing countries and among immigrants. Our primary objective was to systematically review the epidemiology of IMIDs in immigrants and conduct a meta-analysis to estimate the risk of IMIDs in immigrant populations according to their origin and destination countries. METHODS: We systematically searched five biomedical databases and reviewed population-based studies, from inception through August 2018, that reported incidence or prevalence data of inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis (AS) or psoriasis and psoriatic arthritis (PPA) among immigrants and the host population. RESULTS: The incidence and prevalence of IMIDs among immigrants differ from host populations, and evolve over subsequent generations. The risk of IBD among immigrants approximates that in hosts, especially among South Asians, with ulcerative colitis incidence changing prior to Crohn’s disease incidence. MS risk is highest in Iranian immigrants, T1D in African immigrants and SLE in African and Iraqi immigrants. Data on other IMIDs are sparse. Significant heterogeneity between the studies precluded meta-analysis. CONCLUSION: Based on our systematic review, the epidemiology of IMIDs among immigrants varies according to native and host countries, immigrant generation, and IMID type. The rapid evolution suggests a role for non-genetic factors and gene-environment interactions. Future studies should focus on these pattern shifts, given implications of rising global burden of IMIDs and immigration. 2019-07-25 2019-12 /pmc/articles/PMC7382899/ /pubmed/31351784 http://dx.doi.org/10.1016/j.jaut.2019.07.002 Text en This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Agrawal, Manasi
Shah, Shailja
Patel, Anish
Pinotti, Rachel
Colombel, Jean-Frederic
Burisch, Johan
Changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies
title Changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies
title_full Changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies
title_fullStr Changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies
title_full_unstemmed Changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies
title_short Changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies
title_sort changing epidemiology of immune-mediated inflammatory diseases in immigrants: a systematic review of population-based studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382899/
https://www.ncbi.nlm.nih.gov/pubmed/31351784
http://dx.doi.org/10.1016/j.jaut.2019.07.002
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