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The protein expression profile of ACE2 in human tissues
The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383091/ https://www.ncbi.nlm.nih.gov/pubmed/32715618 http://dx.doi.org/10.15252/msb.20209610 |
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author | Hikmet, Feria Méar, Loren Edvinsson, Åsa Micke, Patrick Uhlén, Mathias Lindskog, Cecilia |
author_facet | Hikmet, Feria Méar, Loren Edvinsson, Åsa Micke, Patrick Uhlén, Mathias Lindskog, Cecilia |
author_sort | Hikmet, Feria |
collection | PubMed |
description | The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection. |
format | Online Article Text |
id | pubmed-7383091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73830912020-07-28 The protein expression profile of ACE2 in human tissues Hikmet, Feria Méar, Loren Edvinsson, Åsa Micke, Patrick Uhlén, Mathias Lindskog, Cecilia Mol Syst Biol Articles The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection. John Wiley and Sons Inc. 2020-07-26 /pmc/articles/PMC7383091/ /pubmed/32715618 http://dx.doi.org/10.15252/msb.20209610 Text en © 2020 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Hikmet, Feria Méar, Loren Edvinsson, Åsa Micke, Patrick Uhlén, Mathias Lindskog, Cecilia The protein expression profile of ACE2 in human tissues |
title | The protein expression profile of ACE2 in human tissues |
title_full | The protein expression profile of ACE2 in human tissues |
title_fullStr | The protein expression profile of ACE2 in human tissues |
title_full_unstemmed | The protein expression profile of ACE2 in human tissues |
title_short | The protein expression profile of ACE2 in human tissues |
title_sort | protein expression profile of ace2 in human tissues |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383091/ https://www.ncbi.nlm.nih.gov/pubmed/32715618 http://dx.doi.org/10.15252/msb.20209610 |
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