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A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia

The commonest etiologies of new-onset pancytopenia are congenital bone marrow failure syndromes, marrow space-occupying lesions, infections, and peripheral destruction. Nutritional deficiencies, including folate and vitamin B12, can occasionally cause pancytopenia. We report a 48-year-old gentleman...

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Autores principales: Sasi, Sreethish, Yassin, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383151/
https://www.ncbi.nlm.nih.gov/pubmed/32774276
http://dx.doi.org/10.1159/000507981
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author Sasi, Sreethish
Yassin, Mohamed A.
author_facet Sasi, Sreethish
Yassin, Mohamed A.
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description The commonest etiologies of new-onset pancytopenia are congenital bone marrow failure syndromes, marrow space-occupying lesions, infections, and peripheral destruction. Nutritional deficiencies, including folate and vitamin B12, can occasionally cause pancytopenia. We report a 48-year-old gentleman who presented with a 1-week history of dizziness and upper gastrointestinal bleeding. Laboratory evaluation revealed pancytopenia, macrocytosis, toxic neutrophils, hemolysis, suppressed reticulocyte count, positive direct anti-globulin test (DAT), severely reduced B12 levels, and positive anti-intrinsic factor and anti-parietal cell antibodies. He was started on weekly intramuscular B12 supplementation and showed improvement in blood cell counts during follow-up. Recognition of B12 deficiency as a cause of pancytopenia and DAT-positive autoimmune hemolytic anemia can help to avoid unwanted investigations and aid in early diagnosis and treatment.
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spelling pubmed-73831512020-08-07 A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia Sasi, Sreethish Yassin, Mohamed A. Case Rep Oncol Case Report The commonest etiologies of new-onset pancytopenia are congenital bone marrow failure syndromes, marrow space-occupying lesions, infections, and peripheral destruction. Nutritional deficiencies, including folate and vitamin B12, can occasionally cause pancytopenia. We report a 48-year-old gentleman who presented with a 1-week history of dizziness and upper gastrointestinal bleeding. Laboratory evaluation revealed pancytopenia, macrocytosis, toxic neutrophils, hemolysis, suppressed reticulocyte count, positive direct anti-globulin test (DAT), severely reduced B12 levels, and positive anti-intrinsic factor and anti-parietal cell antibodies. He was started on weekly intramuscular B12 supplementation and showed improvement in blood cell counts during follow-up. Recognition of B12 deficiency as a cause of pancytopenia and DAT-positive autoimmune hemolytic anemia can help to avoid unwanted investigations and aid in early diagnosis and treatment. S. Karger AG 2020-07-02 /pmc/articles/PMC7383151/ /pubmed/32774276 http://dx.doi.org/10.1159/000507981 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Sasi, Sreethish
Yassin, Mohamed A.
A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia
title A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia
title_full A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia
title_fullStr A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia
title_full_unstemmed A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia
title_short A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia
title_sort rare case of acquired hemolytic anemia and pancytopenia secondary to pernicious anemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383151/
https://www.ncbi.nlm.nih.gov/pubmed/32774276
http://dx.doi.org/10.1159/000507981
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