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Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA

Cortical superficial siderosis (cSS) is a common feature in patients with cerebral amyloid angiopathy (CAA). The correlation between β-amyloid and/or tau pathology and the occurrence of cSS is unclear. We report on an 80-year-old male patient who was diagnosed with probable CAA according to modified...

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Autores principales: Brendel, Matthias, Catak, Cihan, Beyer, Leonie, Linn, Jennifer, Wahl, Hannes, Janowitz, Daniel, Rominger, Axel, Patt, Marianne, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Wollenweber, Frank Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383156/
https://www.ncbi.nlm.nih.gov/pubmed/32774280
http://dx.doi.org/10.1159/000506765
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author Brendel, Matthias
Catak, Cihan
Beyer, Leonie
Linn, Jennifer
Wahl, Hannes
Janowitz, Daniel
Rominger, Axel
Patt, Marianne
Barthel, Henryk
Sabri, Osama
Bartenstein, Peter
Wollenweber, Frank Arne
author_facet Brendel, Matthias
Catak, Cihan
Beyer, Leonie
Linn, Jennifer
Wahl, Hannes
Janowitz, Daniel
Rominger, Axel
Patt, Marianne
Barthel, Henryk
Sabri, Osama
Bartenstein, Peter
Wollenweber, Frank Arne
author_sort Brendel, Matthias
collection PubMed
description Cortical superficial siderosis (cSS) is a common feature in patients with cerebral amyloid angiopathy (CAA). The correlation between β-amyloid and/or tau pathology and the occurrence of cSS is unclear. We report on an 80-year-old male patient who was diagnosed with probable CAA according to modified Boston criteria and underwent longitudinal magnetic resonance imaging, amyloid positron emission tomography (PET), and additional tau PET imaging. Amyloid deposition presented predominantly in the contralateral hemisphere not affected by cSS. In contrast, tau deposition was predominantly overlapping with brain regions affected by cSS. Amyloid deposition was not different in the vicinity of cSS whereas tau depositions were elevated in the vicinity of CSS-affected regions compared to non-cSS-affected brain regions. This case of probable CAA suggests that cSS may be associated with a locally elevated tau pathology but not with increased fibrillary amyloid deposition.
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spelling pubmed-73831562020-08-07 Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA Brendel, Matthias Catak, Cihan Beyer, Leonie Linn, Jennifer Wahl, Hannes Janowitz, Daniel Rominger, Axel Patt, Marianne Barthel, Henryk Sabri, Osama Bartenstein, Peter Wollenweber, Frank Arne Case Rep Neurol Single Case – General Neurology Cortical superficial siderosis (cSS) is a common feature in patients with cerebral amyloid angiopathy (CAA). The correlation between β-amyloid and/or tau pathology and the occurrence of cSS is unclear. We report on an 80-year-old male patient who was diagnosed with probable CAA according to modified Boston criteria and underwent longitudinal magnetic resonance imaging, amyloid positron emission tomography (PET), and additional tau PET imaging. Amyloid deposition presented predominantly in the contralateral hemisphere not affected by cSS. In contrast, tau deposition was predominantly overlapping with brain regions affected by cSS. Amyloid deposition was not different in the vicinity of cSS whereas tau depositions were elevated in the vicinity of CSS-affected regions compared to non-cSS-affected brain regions. This case of probable CAA suggests that cSS may be associated with a locally elevated tau pathology but not with increased fibrillary amyloid deposition. S. Karger AG 2020-06-29 /pmc/articles/PMC7383156/ /pubmed/32774280 http://dx.doi.org/10.1159/000506765 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case – General Neurology
Brendel, Matthias
Catak, Cihan
Beyer, Leonie
Linn, Jennifer
Wahl, Hannes
Janowitz, Daniel
Rominger, Axel
Patt, Marianne
Barthel, Henryk
Sabri, Osama
Bartenstein, Peter
Wollenweber, Frank Arne
Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA
title Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA
title_full Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA
title_fullStr Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA
title_full_unstemmed Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA
title_short Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA
title_sort colocalization of tau but not β-amyloid with cortical superficial siderosis in a case with probable caa
topic Single Case – General Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383156/
https://www.ncbi.nlm.nih.gov/pubmed/32774280
http://dx.doi.org/10.1159/000506765
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