Cargando…

Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib

This is a case report on a 69-year-old woman who was diagnosed with malignant melanoma presenting in the lung. A complete staging workup was performed by her oncologist, with no skin lesion identified as a primary. CT-guided needle biopsy of the lung nodule was completed, with pathology revealing at...

Descripción completa

Detalles Bibliográficos
Autores principales: Landgraf, Layla G., Malias, Mark A., Patterson, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383193/
https://www.ncbi.nlm.nih.gov/pubmed/32774277
http://dx.doi.org/10.1159/000508093
_version_ 1783563398739394560
author Landgraf, Layla G.
Malias, Mark A.
Patterson, Stephen J.
author_facet Landgraf, Layla G.
Malias, Mark A.
Patterson, Stephen J.
author_sort Landgraf, Layla G.
collection PubMed
description This is a case report on a 69-year-old woman who was diagnosed with malignant melanoma presenting in the lung. A complete staging workup was performed by her oncologist, with no skin lesion identified as a primary. CT-guided needle biopsy of the lung nodule was completed, with pathology revealing atypical cells consistent with malignant melanoma. Following full body examination by the cutaneous oncologist, a robotic wedge resection and lymph node dissection accompanied by bronchoscopy were performed. Molecular testing (Caris Life Sciences) of the surgical tumor specimen revealed pathological BRAF DNA mutation in exon 15/p.V600K. The patient was initially treated with nivolumab, then treated with a combination of dabrafenib and trametinib at recurrence.
format Online
Article
Text
id pubmed-7383193
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-73831932020-08-07 Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib Landgraf, Layla G. Malias, Mark A. Patterson, Stephen J. Case Rep Oncol Case Report This is a case report on a 69-year-old woman who was diagnosed with malignant melanoma presenting in the lung. A complete staging workup was performed by her oncologist, with no skin lesion identified as a primary. CT-guided needle biopsy of the lung nodule was completed, with pathology revealing atypical cells consistent with malignant melanoma. Following full body examination by the cutaneous oncologist, a robotic wedge resection and lymph node dissection accompanied by bronchoscopy were performed. Molecular testing (Caris Life Sciences) of the surgical tumor specimen revealed pathological BRAF DNA mutation in exon 15/p.V600K. The patient was initially treated with nivolumab, then treated with a combination of dabrafenib and trametinib at recurrence. S. Karger AG 2020-07-07 /pmc/articles/PMC7383193/ /pubmed/32774277 http://dx.doi.org/10.1159/000508093 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Landgraf, Layla G.
Malias, Mark A.
Patterson, Stephen J.
Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib
title Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib
title_full Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib
title_fullStr Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib
title_full_unstemmed Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib
title_short Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib
title_sort primary melanoma of the lung treated with surgery, dabrafenib and trametinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383193/
https://www.ncbi.nlm.nih.gov/pubmed/32774277
http://dx.doi.org/10.1159/000508093
work_keys_str_mv AT landgraflaylag primarymelanomaofthelungtreatedwithsurgerydabrafenibandtrametinib
AT maliasmarka primarymelanomaofthelungtreatedwithsurgerydabrafenibandtrametinib
AT pattersonstephenj primarymelanomaofthelungtreatedwithsurgerydabrafenibandtrametinib