Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

Calorie restriction (CR) extends lifespan through several intracellular mechanisms, including increased DNA repair, leading to fewer DNA mutations that cause age-related pathologies. However, it remains unknown how CR acts on mutation retention at the tissue level. Here, we use Cre-mediated DNA reco...

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Detalles Bibliográficos
Autores principales: Bruens, Lotte, Ellenbroek, Saskia Inge Johanna, Suijkerbuijk, Saskia Jacoba Elisabeth, Azkanaz, Maria, Hale, Alexander James, Toonen, Pim, Flanagan, Dustin James, Sansom, Owen James, Snippert, Hugo Johannes, van Rheenen, Jacco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383228/
https://www.ncbi.nlm.nih.gov/pubmed/32698002
http://dx.doi.org/10.1016/j.celrep.2020.107937

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