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A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program

Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic development that coincides with extensive epigenetic reprogramming. Complex manipulation techniques and maternal stores of proteins preclude large-scale functional screens for ZGA regulators within early embryos. Here...

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Detalles Bibliográficos
Autores principales:	Alda-Catalinas, Celia, Bredikhin, Danila, Hernando-Herraez, Irene, Santos, Fátima, Kubinyecz, Oana, Eckersley-Maslin, Mélanie A., Stegle, Oliver, Reik, Wolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383230/ https://www.ncbi.nlm.nih.gov/pubmed/32634384 http://dx.doi.org/10.1016/j.cels.2020.06.004

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