An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide over...

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Detalles Bibliográficos
Autores principales: Pei, Ke, Gui, Ting, Kan, Dongfang, Feng, Huichao, Jin, Yanqiang, Yang, Ying, Zhang, Qian, Du, Ziwei, Gai, Zhibo, Wu, Jibiao, Li, Yunlun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383338/
https://www.ncbi.nlm.nih.gov/pubmed/32733940
http://dx.doi.org/10.1155/2020/4020249
Descripción
Sumario:The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.

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