An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide over...

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Autores principales: Pei, Ke, Gui, Ting, Kan, Dongfang, Feng, Huichao, Jin, Yanqiang, Yang, Ying, Zhang, Qian, Du, Ziwei, Gai, Zhibo, Wu, Jibiao, Li, Yunlun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383338/
https://www.ncbi.nlm.nih.gov/pubmed/32733940
http://dx.doi.org/10.1155/2020/4020249
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author Pei, Ke
Gui, Ting
Kan, Dongfang
Feng, Huichao
Jin, Yanqiang
Yang, Ying
Zhang, Qian
Du, Ziwei
Gai, Zhibo
Wu, Jibiao
Li, Yunlun
author_facet Pei, Ke
Gui, Ting
Kan, Dongfang
Feng, Huichao
Jin, Yanqiang
Yang, Ying
Zhang, Qian
Du, Ziwei
Gai, Zhibo
Wu, Jibiao
Li, Yunlun
author_sort Pei, Ke
collection PubMed
description The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.
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spelling pubmed-73833382020-07-29 An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease Pei, Ke Gui, Ting Kan, Dongfang Feng, Huichao Jin, Yanqiang Yang, Ying Zhang, Qian Du, Ziwei Gai, Zhibo Wu, Jibiao Li, Yunlun Biomed Res Int Review Article The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies. Hindawi 2020-07-18 /pmc/articles/PMC7383338/ /pubmed/32733940 http://dx.doi.org/10.1155/2020/4020249 Text en Copyright © 2020 Ke Pei et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pei, Ke
Gui, Ting
Kan, Dongfang
Feng, Huichao
Jin, Yanqiang
Yang, Ying
Zhang, Qian
Du, Ziwei
Gai, Zhibo
Wu, Jibiao
Li, Yunlun
An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease
title An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease
title_full An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease
title_fullStr An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease
title_full_unstemmed An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease
title_short An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease
title_sort overview of lipid metabolism and nonalcoholic fatty liver disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383338/
https://www.ncbi.nlm.nih.gov/pubmed/32733940
http://dx.doi.org/10.1155/2020/4020249
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