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Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions

AIMS: Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by i...

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Autores principales: Chinen, Shigeki, Miyagi, Takuya, Murakami, Yoshiya, Takatori, Mitsuyoshi, Sakihama, Shugo, Nakazato, Iwao, Kariya, Yoshiyuki, Yamaguchi, Sayaka, Takahashi, Kenzo, Karube, Kennosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383570/
https://www.ncbi.nlm.nih.gov/pubmed/32162348
http://dx.doi.org/10.1111/his.14102
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author Chinen, Shigeki
Miyagi, Takuya
Murakami, Yoshiya
Takatori, Mitsuyoshi
Sakihama, Shugo
Nakazato, Iwao
Kariya, Yoshiyuki
Yamaguchi, Sayaka
Takahashi, Kenzo
Karube, Kennosuke
author_facet Chinen, Shigeki
Miyagi, Takuya
Murakami, Yoshiya
Takatori, Mitsuyoshi
Sakihama, Shugo
Nakazato, Iwao
Kariya, Yoshiyuki
Yamaguchi, Sayaka
Takahashi, Kenzo
Karube, Kennosuke
author_sort Chinen, Shigeki
collection PubMed
description AIMS: Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by infection with human T cell leukaemia virus type I (HTLV‐1), which is frequently accompanied by cutaneous lesions. However, the detailed clinicopathological characteristics of the dermatopathic reaction of lymph nodes in ATLL patients and HTLV‐1 carriers, addressed in this study, remains to be clarified. METHODS AND RESULTS: We retrospectively analysed 18 nodal lesions with dermatopathic reaction in HTLV‐1 carriers. Axillary and inguinal lymph nodes were the primary affected tissues. Three cases with atypical lymphoid cell infiltration were defined as ATLL with dermatopathic reaction (ATLL‐D), showing an abnormal T cell immunophenotype and T cell monoclonality. Two of the three ATLL‐D patients died 14 and 7 months after diagnosis (the third case had a very short follow‐up). The other 15 patients were indistinguishable from reactive lesions and were defined as HTLV‐1‐associated lymphadenitis with dermatopathic reaction (HAL‐D). They showed an indolent clinical course, with only one case eventually transforming to aggressive disease. CONCLUSIONS: Lymph node lesions accompanied by dermatopathic reaction in HTLV1 carriers represent a spectrum that includes reactive and neoplastic conditions. HAL‐D should be distinguished from ATLL‐D, especially to avoid overtreatment.
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spelling pubmed-73835702020-07-27 Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions Chinen, Shigeki Miyagi, Takuya Murakami, Yoshiya Takatori, Mitsuyoshi Sakihama, Shugo Nakazato, Iwao Kariya, Yoshiyuki Yamaguchi, Sayaka Takahashi, Kenzo Karube, Kennosuke Histopathology Original Articles AIMS: Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by infection with human T cell leukaemia virus type I (HTLV‐1), which is frequently accompanied by cutaneous lesions. However, the detailed clinicopathological characteristics of the dermatopathic reaction of lymph nodes in ATLL patients and HTLV‐1 carriers, addressed in this study, remains to be clarified. METHODS AND RESULTS: We retrospectively analysed 18 nodal lesions with dermatopathic reaction in HTLV‐1 carriers. Axillary and inguinal lymph nodes were the primary affected tissues. Three cases with atypical lymphoid cell infiltration were defined as ATLL with dermatopathic reaction (ATLL‐D), showing an abnormal T cell immunophenotype and T cell monoclonality. Two of the three ATLL‐D patients died 14 and 7 months after diagnosis (the third case had a very short follow‐up). The other 15 patients were indistinguishable from reactive lesions and were defined as HTLV‐1‐associated lymphadenitis with dermatopathic reaction (HAL‐D). They showed an indolent clinical course, with only one case eventually transforming to aggressive disease. CONCLUSIONS: Lymph node lesions accompanied by dermatopathic reaction in HTLV1 carriers represent a spectrum that includes reactive and neoplastic conditions. HAL‐D should be distinguished from ATLL‐D, especially to avoid overtreatment. John Wiley and Sons Inc. 2020-06-18 2020-07 /pmc/articles/PMC7383570/ /pubmed/32162348 http://dx.doi.org/10.1111/his.14102 Text en © 2020 The Authors. Histopathology published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Chinen, Shigeki
Miyagi, Takuya
Murakami, Yoshiya
Takatori, Mitsuyoshi
Sakihama, Shugo
Nakazato, Iwao
Kariya, Yoshiyuki
Yamaguchi, Sayaka
Takahashi, Kenzo
Karube, Kennosuke
Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions
title Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions
title_full Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions
title_fullStr Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions
title_full_unstemmed Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions
title_short Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions
title_sort dermatopathic reaction of lymph nodes in htlv‐1 carriers: a spectrum of reactive and neoplastic lesions
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383570/
https://www.ncbi.nlm.nih.gov/pubmed/32162348
http://dx.doi.org/10.1111/his.14102
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