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Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions
AIMS: Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by i...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383570/ https://www.ncbi.nlm.nih.gov/pubmed/32162348 http://dx.doi.org/10.1111/his.14102 |
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author | Chinen, Shigeki Miyagi, Takuya Murakami, Yoshiya Takatori, Mitsuyoshi Sakihama, Shugo Nakazato, Iwao Kariya, Yoshiyuki Yamaguchi, Sayaka Takahashi, Kenzo Karube, Kennosuke |
author_facet | Chinen, Shigeki Miyagi, Takuya Murakami, Yoshiya Takatori, Mitsuyoshi Sakihama, Shugo Nakazato, Iwao Kariya, Yoshiyuki Yamaguchi, Sayaka Takahashi, Kenzo Karube, Kennosuke |
author_sort | Chinen, Shigeki |
collection | PubMed |
description | AIMS: Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by infection with human T cell leukaemia virus type I (HTLV‐1), which is frequently accompanied by cutaneous lesions. However, the detailed clinicopathological characteristics of the dermatopathic reaction of lymph nodes in ATLL patients and HTLV‐1 carriers, addressed in this study, remains to be clarified. METHODS AND RESULTS: We retrospectively analysed 18 nodal lesions with dermatopathic reaction in HTLV‐1 carriers. Axillary and inguinal lymph nodes were the primary affected tissues. Three cases with atypical lymphoid cell infiltration were defined as ATLL with dermatopathic reaction (ATLL‐D), showing an abnormal T cell immunophenotype and T cell monoclonality. Two of the three ATLL‐D patients died 14 and 7 months after diagnosis (the third case had a very short follow‐up). The other 15 patients were indistinguishable from reactive lesions and were defined as HTLV‐1‐associated lymphadenitis with dermatopathic reaction (HAL‐D). They showed an indolent clinical course, with only one case eventually transforming to aggressive disease. CONCLUSIONS: Lymph node lesions accompanied by dermatopathic reaction in HTLV1 carriers represent a spectrum that includes reactive and neoplastic conditions. HAL‐D should be distinguished from ATLL‐D, especially to avoid overtreatment. |
format | Online Article Text |
id | pubmed-7383570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73835702020-07-27 Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions Chinen, Shigeki Miyagi, Takuya Murakami, Yoshiya Takatori, Mitsuyoshi Sakihama, Shugo Nakazato, Iwao Kariya, Yoshiyuki Yamaguchi, Sayaka Takahashi, Kenzo Karube, Kennosuke Histopathology Original Articles AIMS: Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by infection with human T cell leukaemia virus type I (HTLV‐1), which is frequently accompanied by cutaneous lesions. However, the detailed clinicopathological characteristics of the dermatopathic reaction of lymph nodes in ATLL patients and HTLV‐1 carriers, addressed in this study, remains to be clarified. METHODS AND RESULTS: We retrospectively analysed 18 nodal lesions with dermatopathic reaction in HTLV‐1 carriers. Axillary and inguinal lymph nodes were the primary affected tissues. Three cases with atypical lymphoid cell infiltration were defined as ATLL with dermatopathic reaction (ATLL‐D), showing an abnormal T cell immunophenotype and T cell monoclonality. Two of the three ATLL‐D patients died 14 and 7 months after diagnosis (the third case had a very short follow‐up). The other 15 patients were indistinguishable from reactive lesions and were defined as HTLV‐1‐associated lymphadenitis with dermatopathic reaction (HAL‐D). They showed an indolent clinical course, with only one case eventually transforming to aggressive disease. CONCLUSIONS: Lymph node lesions accompanied by dermatopathic reaction in HTLV1 carriers represent a spectrum that includes reactive and neoplastic conditions. HAL‐D should be distinguished from ATLL‐D, especially to avoid overtreatment. John Wiley and Sons Inc. 2020-06-18 2020-07 /pmc/articles/PMC7383570/ /pubmed/32162348 http://dx.doi.org/10.1111/his.14102 Text en © 2020 The Authors. Histopathology published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Chinen, Shigeki Miyagi, Takuya Murakami, Yoshiya Takatori, Mitsuyoshi Sakihama, Shugo Nakazato, Iwao Kariya, Yoshiyuki Yamaguchi, Sayaka Takahashi, Kenzo Karube, Kennosuke Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions |
title | Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions |
title_full | Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions |
title_fullStr | Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions |
title_full_unstemmed | Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions |
title_short | Dermatopathic reaction of lymph nodes in HTLV‐1 carriers: a spectrum of reactive and neoplastic lesions |
title_sort | dermatopathic reaction of lymph nodes in htlv‐1 carriers: a spectrum of reactive and neoplastic lesions |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383570/ https://www.ncbi.nlm.nih.gov/pubmed/32162348 http://dx.doi.org/10.1111/his.14102 |
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